3-Aroylindoles have been prepared via copper-catalyzed cyclization of N-(2-iodoaryl)enaminones, readily available from 2-iodoanilines and α,β-ynones. The reaction tolerates a variety of useful functionalities including ether, keto, cyano, bromo, and chloro substituents. This indole synthesis can also be carried out from 2-iodoanilines and α,β-ynones through a sequential process that omits the isolation of enaminone intermediates. © Georg Thieme Verlag Stuttgart.

3-Aroylindoles via copper-catalyzed cyclization of N-(2-iodoaryl)enaminones / Roberta, Bernini; Cacchi, Sandro; Fabrizi, Giancarlo; Eleonora, Filisti; Sferrazza, Alessio. - In: SYNLETT. - ISSN 0936-5214. - 2009:9(2009), pp. 1480-1484. [10.1055/s-0029-1216742]

3-Aroylindoles via copper-catalyzed cyclization of N-(2-iodoaryl)enaminones

CACCHI, Sandro;FABRIZI, Giancarlo;SFERRAZZA, ALESSIO
2009

Abstract

3-Aroylindoles have been prepared via copper-catalyzed cyclization of N-(2-iodoaryl)enaminones, readily available from 2-iodoanilines and α,β-ynones. The reaction tolerates a variety of useful functionalities including ether, keto, cyano, bromo, and chloro substituents. This indole synthesis can also be carried out from 2-iodoanilines and α,β-ynones through a sequential process that omits the isolation of enaminone intermediates. © Georg Thieme Verlag Stuttgart.
catalysis; copper; cyclization; enaminones; indoles
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3-Aroylindoles via copper-catalyzed cyclization of N-(2-iodoaryl)enaminones / Roberta, Bernini; Cacchi, Sandro; Fabrizi, Giancarlo; Eleonora, Filisti; Sferrazza, Alessio. - In: SYNLETT. - ISSN 0936-5214. - 2009:9(2009), pp. 1480-1484. [10.1055/s-0029-1216742]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/74122
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