Non-verbal behaviour of 22 unipolar, non-delusional depressed outpatients was video-recorded during psychiatric interview to determine whether response to tricyclic treatment (50-100 mg/day of amitriptyline for 5 consecutive weeks) could be predicted on the basis of the ethological profile at baseline. At the end of the study, patients were divided into two treatment outcome groups on the basis of their final Hamilton Depression Rating Scale (HDRS) scores. At baseline, responders (n=14, HDRS score ≤ 10) and non-responders (n=8, HDRS score > 10) did not differ with respect to sex, age, education, DSM-III diagnosis, and HDRS score. In contrast, ethological profiles of the two treatment outcoume groups at baseline were different, with non-responders showing significantly more assertive and affiliative behaviours. The results are discussed in the light of previous studies which have identified subgroups of depressive patients with different responsiveness to tricyclic treatment.
ETHOLOGICAL PREDICTORS OF AMITRIPTYLINE RESPONSE IN DEPRESSED OUTPATIENTS / Alfonso, Troisi; Augusto, Pasini; Bersani, Giuseppe; A., Grissini; Nicola, Ciani. - In: JOURNAL OF AFFECTIVE DISORDERS. - ISSN 0165-0327. - STAMPA. - 17:2(1989), pp. 129-136. [10.1016/0165-0327(89)90035-9]
ETHOLOGICAL PREDICTORS OF AMITRIPTYLINE RESPONSE IN DEPRESSED OUTPATIENTS
BERSANI, Giuseppe;
1989
Abstract
Non-verbal behaviour of 22 unipolar, non-delusional depressed outpatients was video-recorded during psychiatric interview to determine whether response to tricyclic treatment (50-100 mg/day of amitriptyline for 5 consecutive weeks) could be predicted on the basis of the ethological profile at baseline. At the end of the study, patients were divided into two treatment outcome groups on the basis of their final Hamilton Depression Rating Scale (HDRS) scores. At baseline, responders (n=14, HDRS score ≤ 10) and non-responders (n=8, HDRS score > 10) did not differ with respect to sex, age, education, DSM-III diagnosis, and HDRS score. In contrast, ethological profiles of the two treatment outcoume groups at baseline were different, with non-responders showing significantly more assertive and affiliative behaviours. The results are discussed in the light of previous studies which have identified subgroups of depressive patients with different responsiveness to tricyclic treatment.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
