Human regulatory T cells (Tregs) comprise an array of distinct subsets displaying diverse functions in response to microenvironmental signals. Here, we review our recent findings demonstrating the preferential accumulation of uncommitted, Th1-like and OX40-Tregs in non-cirrhotic tissues in contrast to the presence of committed, Th1-suppressing and OX40(+) Tregs in cirrhotic and tumor contexts in human liver affected by chronic hepatitis C.
'Hardcore' OX40(+) immunosuppressive regulatory T cells in hepatic cirrhosis and cancer / Piconese, Silvia; Timperi, Eleonora; Barnaba, Vincenzo. - In: ONCOIMMUNOLOGY. - ISSN 2162-4011. - ELETTRONICO. - 3:6(2014), p. e29257. [10.4161/onci.29257]
'Hardcore' OX40(+) immunosuppressive regulatory T cells in hepatic cirrhosis and cancer
PICONESE, SILVIA;TIMPERI, ELEONORA;BARNABA, Vincenzo
2014
Abstract
Human regulatory T cells (Tregs) comprise an array of distinct subsets displaying diverse functions in response to microenvironmental signals. Here, we review our recent findings demonstrating the preferential accumulation of uncommitted, Th1-like and OX40-Tregs in non-cirrhotic tissues in contrast to the presence of committed, Th1-suppressing and OX40(+) Tregs in cirrhotic and tumor contexts in human liver affected by chronic hepatitis C.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
