Since its first description in 1951, a timely diagnosis of medullary thyroid carcinoma (MTC) may represent a diagnostic challenge in clinical practice. Several contributions have been addressed to the treatment and follow-up of MTC, but review articles focused on the diagnostic problems of this cancer in clinical practice are sparse. As a delayed diagnosis and an inadequate initial treatment may severely affect the prognosis of this thyroid malignancy, the appropriate use and the correct interpretation of the available diagnostic tools for MTC are of crucial importance. The purpose of the present article is to provide an easy-to-use guide reviewing the main issues of MTC diagnosis: (1) basal serum calcitonin; (2) stimulated serum calcitonin; (3) additional serum markers for MTC; (4) ultrasound and other imaging techniques; (5) fine-needle aspiration (FNA) cytology; (6) calcitonin measurement on FNA washout; (7) rearranged during transfection (RET) mutations; and (8) scope of the problem. (C) 2014 Wiley Periodicals, Inc.

Medullary thyroid cancer diagnosis: An appraisal / Pierpaolo, Trimboli; Luca, Giovanella; Anna, Crescenzi; Romanelli, Francesco; Valabrega, Stefano; Giuseppe, Spriano; Nadia, Cremonini; Rinaldo, Guglielmi; Enrico, Papini. - In: HEAD & NECK. - ISSN 1043-3074. - STAMPA. - 36:8(2014), pp. 1216-1223. [10.1002/hed.23449]

Medullary thyroid cancer diagnosis: An appraisal

Anna Crescenzi;ROMANELLI, Francesco;VALABREGA, Stefano;
2014

Abstract

Since its first description in 1951, a timely diagnosis of medullary thyroid carcinoma (MTC) may represent a diagnostic challenge in clinical practice. Several contributions have been addressed to the treatment and follow-up of MTC, but review articles focused on the diagnostic problems of this cancer in clinical practice are sparse. As a delayed diagnosis and an inadequate initial treatment may severely affect the prognosis of this thyroid malignancy, the appropriate use and the correct interpretation of the available diagnostic tools for MTC are of crucial importance. The purpose of the present article is to provide an easy-to-use guide reviewing the main issues of MTC diagnosis: (1) basal serum calcitonin; (2) stimulated serum calcitonin; (3) additional serum markers for MTC; (4) ultrasound and other imaging techniques; (5) fine-needle aspiration (FNA) cytology; (6) calcitonin measurement on FNA washout; (7) rearranged during transfection (RET) mutations; and (8) scope of the problem. (C) 2014 Wiley Periodicals, Inc.
2014
rearranged during transfection (ret); thyroid; calcitonin; cytology; carcinoma
01 Pubblicazione su rivista::01a Articolo in rivista
Medullary thyroid cancer diagnosis: An appraisal / Pierpaolo, Trimboli; Luca, Giovanella; Anna, Crescenzi; Romanelli, Francesco; Valabrega, Stefano; Giuseppe, Spriano; Nadia, Cremonini; Rinaldo, Guglielmi; Enrico, Papini. - In: HEAD & NECK. - ISSN 1043-3074. - STAMPA. - 36:8(2014), pp. 1216-1223. [10.1002/hed.23449]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/727089
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 21
  • Scopus 68
  • ???jsp.display-item.citation.isi??? 64
social impact