ABSTRACT Background: The present study aims to assess qualitative and quantitative characteristics of tear film and corneal related impairment and to evaluate the quality of life in a cohort of non-exophthalmic Graves' disease (GD) patients. Methods: The series comprised 50 eyes from 25 newly diagnosed GD patients with no proptosis. As control group, 56 eyes of 28 thyroid disease-free subjects were enrolled. Results: The results of Schirmer I and II, break-up time, and Oxford scheme showed a significant difference between GD and controls. By ocular surface disease index (OSDI) questionnaire, eleven (44%) GD patients had normal ocular surface, while two (8%) had mild, four (16%) had moderate, and eight (32%) had severe dry eye. The mean score of the OSDI in the GD group was significantly (p < 0.001) higher with respect to the control group. Conclusions: This study shows that the tear film and cornea are damaged in newly non-exophthalmic GD subjects.
Dry Eye Syndrome in Non-Exophthalmic Graves' Disease / Bruscolini, A.; Abbouda, Alessandro; Locuratolo, N.; Restivo, L.; Trimboli, P.; Romanelli, Francesco. - In: SEMINARS IN OPHTHALMOLOGY. - ISSN 0882-0538. - ELETTRONICO. - (2014), pp. 1-5. [10.3109/08820538.2013.874491]
Dry Eye Syndrome in Non-Exophthalmic Graves' Disease.
A. Bruscolini;ABBOUDA, ALESSANDRO;ROMANELLI, Francesco
2014
Abstract
ABSTRACT Background: The present study aims to assess qualitative and quantitative characteristics of tear film and corneal related impairment and to evaluate the quality of life in a cohort of non-exophthalmic Graves' disease (GD) patients. Methods: The series comprised 50 eyes from 25 newly diagnosed GD patients with no proptosis. As control group, 56 eyes of 28 thyroid disease-free subjects were enrolled. Results: The results of Schirmer I and II, break-up time, and Oxford scheme showed a significant difference between GD and controls. By ocular surface disease index (OSDI) questionnaire, eleven (44%) GD patients had normal ocular surface, while two (8%) had mild, four (16%) had moderate, and eight (32%) had severe dry eye. The mean score of the OSDI in the GD group was significantly (p < 0.001) higher with respect to the control group. Conclusions: This study shows that the tear film and cornea are damaged in newly non-exophthalmic GD subjects.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
