Purpose: Thyroid malignancies can be treated by surgery followed by ablation of the remnant tissue with I-131. As iodide removal from the body occurs by renal extraction, in patients suffering from end-stage renal disease it is necessary to properly evaluate both timing and method of the extracorporeal treatment. Methods: We present two patients on regular hemodialysis, admitted in isolation to the Nuclear Medicine Department and treated with I-131 for thyroid carcinoma diagnosed during the check-up for transplantation. Both patients underwent two hemodialysis sessions with a portable machine for CRRT (continuous renal replacement therapy), 24 and 48 hours after the administration of 50 mCi of I-131. The nursing staff were monitored with a dosimeter. Radioactivity of the patients, dialysate and urines were measured during hemodialysis. Results: The greater reduction was obtained with the first dialysis, but in both patients a further, though shorter, hemodialysis at 48 hours was necessary for reaching a patient's radioactivity compatible with discharge. Radioactivity measured in the dialysate demonstrated the almost total removal of radioiodine by dialysis alone. In both patients, follow-up exams revealed a complete ablation of thyroid tissue, without signs of local recurrence. The dose of radioactivity of the dialysis staff was below allowable limits. Conclusions: We conclude that a successful reduction of radioactivity, without dispersing its therapeutic efficacy, can be obtained with daily hemodialysis with a CRRT machine in patients in isolation treated with I-131. A therapeutic model is proposed.

Hemodialysis in patients requiring 131I treatment for thyroid carcinoma / C. Fofi F., Festuccia; S., Barberi; F., Apponi; L., Chiacchiararelli; Scopinaro, Francesco; Punzo, Giorgio; Mene', Paolo. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - STAMPA. - 36:(2013), pp. 439-443. [10.5301/ijao.5000192]

Hemodialysis in patients requiring 131I treatment for thyroid carcinoma.

SCOPINARO, Francesco;PUNZO, Giorgio;MENE', Paolo
2013

Abstract

Purpose: Thyroid malignancies can be treated by surgery followed by ablation of the remnant tissue with I-131. As iodide removal from the body occurs by renal extraction, in patients suffering from end-stage renal disease it is necessary to properly evaluate both timing and method of the extracorporeal treatment. Methods: We present two patients on regular hemodialysis, admitted in isolation to the Nuclear Medicine Department and treated with I-131 for thyroid carcinoma diagnosed during the check-up for transplantation. Both patients underwent two hemodialysis sessions with a portable machine for CRRT (continuous renal replacement therapy), 24 and 48 hours after the administration of 50 mCi of I-131. The nursing staff were monitored with a dosimeter. Radioactivity of the patients, dialysate and urines were measured during hemodialysis. Results: The greater reduction was obtained with the first dialysis, but in both patients a further, though shorter, hemodialysis at 48 hours was necessary for reaching a patient's radioactivity compatible with discharge. Radioactivity measured in the dialysate demonstrated the almost total removal of radioiodine by dialysis alone. In both patients, follow-up exams revealed a complete ablation of thyroid tissue, without signs of local recurrence. The dose of radioactivity of the dialysis staff was below allowable limits. Conclusions: We conclude that a successful reduction of radioactivity, without dispersing its therapeutic efficacy, can be obtained with daily hemodialysis with a CRRT machine in patients in isolation treated with I-131. A therapeutic model is proposed.
2013
01 Pubblicazione su rivista::01a Articolo in rivista
Hemodialysis in patients requiring 131I treatment for thyroid carcinoma / C. Fofi F., Festuccia; S., Barberi; F., Apponi; L., Chiacchiararelli; Scopinaro, Francesco; Punzo, Giorgio; Mene', Paolo. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - STAMPA. - 36:(2013), pp. 439-443. [10.5301/ijao.5000192]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/725870
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