Celiac disease is a chronic disorder caused by dietary gluten in genetically susceptible individuals characterized by an inappropriate immune response. Recently, a new approach based on the detection of serum antibodies towards peptides of gluten (epitopes) has been reported. Here, we present a compact device based on an array of amorphous silicon (a-Si:H) photosensors where different epitopes, which establish immunoreaction in celiac patients, were immobilized on the surface of the device through the deposition of poly(2-hydroxyethyl methacrylate) (PHEMA)polymer brushes. The diagnosis of the celiac disease relies on the detection of the immunoreactions by using a chemiluminescent method. The results demonstrate the specificity and selectivity of the proposed system and show the successful integration of the recognition and detection elements in a single chip to obtain a portable low cost device as a novel tool for the diagnosis of celiac disease.

Array of Amorphous Silicon Photosensors for the Diagnosis of Celiac Disease in Lab-on-Chip System / Caputo, Domenico; Scipinotti, Riccardo; A., De Pastina; Costantini, Francesca; Manetti, Cesare; Nascetti, Augusto; Zahra, Andleeb; DE CESARE, Giampiero. - ELETTRONICO. - (2013), pp. 77-78. ((Intervento presentato al convegno 45th Conference "Gruppo Elettronica" tenutosi a Udine - Italia nel 17-21 giu 2013.

Array of Amorphous Silicon Photosensors for the Diagnosis of Celiac Disease in Lab-on-Chip System

CAPUTO, Domenico;SCIPINOTTI, RICCARDO;COSTANTINI, FRANCESCA;MANETTI, Cesare;NASCETTI, Augusto;ZAHRA, ANDLEEB;DE CESARE, Giampiero
2013

Abstract

Celiac disease is a chronic disorder caused by dietary gluten in genetically susceptible individuals characterized by an inappropriate immune response. Recently, a new approach based on the detection of serum antibodies towards peptides of gluten (epitopes) has been reported. Here, we present a compact device based on an array of amorphous silicon (a-Si:H) photosensors where different epitopes, which establish immunoreaction in celiac patients, were immobilized on the surface of the device through the deposition of poly(2-hydroxyethyl methacrylate) (PHEMA)polymer brushes. The diagnosis of the celiac disease relies on the detection of the immunoreactions by using a chemiluminescent method. The results demonstrate the specificity and selectivity of the proposed system and show the successful integration of the recognition and detection elements in a single chip to obtain a portable low cost device as a novel tool for the diagnosis of celiac disease.
45th Conference "Gruppo Elettronica"
04 Pubblicazione in atti di convegno::04d Abstract in atti di convegno
Array of Amorphous Silicon Photosensors for the Diagnosis of Celiac Disease in Lab-on-Chip System / Caputo, Domenico; Scipinotti, Riccardo; A., De Pastina; Costantini, Francesca; Manetti, Cesare; Nascetti, Augusto; Zahra, Andleeb; DE CESARE, Giampiero. - ELETTRONICO. - (2013), pp. 77-78. ((Intervento presentato al convegno 45th Conference "Gruppo Elettronica" tenutosi a Udine - Italia nel 17-21 giu 2013.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/712261
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