In this editorial we argue that more and more complex classifications for patients with common variable immunodeficiency (CVID) fail to identify those patients at high risk of developing infections. We propose that the minimal requirement to identify such patients is the absolute numbers of total and memory B cells and the IgM response to immunization with polysaccharides. If these data should be confirmed, they will provide the basis for a good classification of a heterogeneous group of patients. This simple, workable classification may result in a clinically useful identification of patients prone to more aggressive infections
In this editorial we argue that more and more complex classifications for patients with common variable immunodeficiency (CVID) fail to identify those patients at high risk of developing infections. We propose that the minimal requirement to identify such patients is the absolute numbers of total and memory B cells and the IgM response to immunization with polysaccharides. If these data should be confirmed, they will provide the basis for a good classification of a heterogeneous group of patients. This simple, workable classification may result in a clinically useful identification of patients prone to more aggressive infections.
COMMON VARIABLE IMMUNODEFICIENCY - NEW INSIGHT INTO THE PATHOGENESIS AND THE QUEST FOR A WORKABLE CLASSIFICATION / Pandolfi, Franco; Milito, Cinzia; Conti, Valentina; D., Pagliari; S., Frosali; R., Cianci; Quinti, Isabella. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - 27:2(2013), pp. 285-289.
COMMON VARIABLE IMMUNODEFICIENCY - NEW INSIGHT INTO THE PATHOGENESIS AND THE QUEST FOR A WORKABLE CLASSIFICATION
PANDOLFI, Franco;MILITO, CINZIA;CONTI, VALENTINA;QUINTI, Isabella
2013
Abstract
In this editorial we argue that more and more complex classifications for patients with common variable immunodeficiency (CVID) fail to identify those patients at high risk of developing infections. We propose that the minimal requirement to identify such patients is the absolute numbers of total and memory B cells and the IgM response to immunization with polysaccharides. If these data should be confirmed, they will provide the basis for a good classification of a heterogeneous group of patients. This simple, workable classification may result in a clinically useful identification of patients prone to more aggressive infectionsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
