Astrocytes accumulate iron under chronic oxidative stress conditions in ageing and neurological disorders. The soybean isoflavone genistein possesses antioxidant properties and selective estrogen-like activities. Here, a possible role of genistein in modulation of iron transport was explored in glial cells. Genistein significantly increased iron export through estrogen receptor-beta-dependent p38 MAPK activation. Evidence is presented that this effect is associated to a p38 MAPK-triggered up-regulation of the iron export system made by ceruloplasmin and ferroportin-1, a pathway requiring activation of the transcription factor C/EBP. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Genistein up-regulates the iron efflux system in glial cells / Tiziana, Persichini; Nunziata, Maio; BONACCORSI DI PATTI, Maria Carmela; Gianluca, Rizzo; Marco, Colasanti; Giovanni, Musci. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 470:2(2010), pp. 145-149. [10.1016/j.neulet.2009.12.074]
Genistein up-regulates the iron efflux system in glial cells
BONACCORSI DI PATTI, Maria Carmela;
2010
Abstract
Astrocytes accumulate iron under chronic oxidative stress conditions in ageing and neurological disorders. The soybean isoflavone genistein possesses antioxidant properties and selective estrogen-like activities. Here, a possible role of genistein in modulation of iron transport was explored in glial cells. Genistein significantly increased iron export through estrogen receptor-beta-dependent p38 MAPK activation. Evidence is presented that this effect is associated to a p38 MAPK-triggered up-regulation of the iron export system made by ceruloplasmin and ferroportin-1, a pathway requiring activation of the transcription factor C/EBP. (C) 2010 Elsevier Ireland Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
