The natural world consists of hierarchical levels of complexity that range from subatomic particles and molecules to ecosystems and beyond. This implies that, in order to explain the features and behavior of a whole system, a theory might be required that would operate at the corresponding hierarchical level, i.e. where self-organization processes take place. In the past, biological research has focused on questions that could be answered by a reductionist program of genetics. The organism (and its development) was considered an epiphenomenona of its genes. However, a profound rethinking of the biological paradigm is now underway and it is likely that such a process will lead to a conceptual revolution emerging from the ashes of reductionism. This revolution implies the search for general principles on which a cogent theory of biology might rely. Because much of the logic of living systems is located at higher levels, it is imperative to focus on them. Indeed, both evolution and physiology work on these levels. Thus, by no means Systems Biology could be considered a ‘simple’ ‘gradual’ extension of Molecular Biology

Theoretical aspects of Systems Biology / Bizzarri, Mariano; Palombo, Alessandro; Cucina, Alessandra. - In: PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY. - ISSN 0079-6107. - STAMPA. - 112:1-2(2013), pp. 33-43. [10.1016/j.pbiomolbio.2013.03.019]

Theoretical aspects of Systems Biology

BIZZARRI, Mariano;PALOMBO, ALESSANDRO;CUCINA, Alessandra
2013

Abstract

The natural world consists of hierarchical levels of complexity that range from subatomic particles and molecules to ecosystems and beyond. This implies that, in order to explain the features and behavior of a whole system, a theory might be required that would operate at the corresponding hierarchical level, i.e. where self-organization processes take place. In the past, biological research has focused on questions that could be answered by a reductionist program of genetics. The organism (and its development) was considered an epiphenomenona of its genes. However, a profound rethinking of the biological paradigm is now underway and it is likely that such a process will lead to a conceptual revolution emerging from the ashes of reductionism. This revolution implies the search for general principles on which a cogent theory of biology might rely. Because much of the logic of living systems is located at higher levels, it is imperative to focus on them. Indeed, both evolution and physiology work on these levels. Thus, by no means Systems Biology could be considered a ‘simple’ ‘gradual’ extension of Molecular Biology
2013
Systems Biology Biophysical constraints Complexity Fractals Non-linearity Morphogenetic field
01 Pubblicazione su rivista::01a Articolo in rivista
Theoretical aspects of Systems Biology / Bizzarri, Mariano; Palombo, Alessandro; Cucina, Alessandra. - In: PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY. - ISSN 0079-6107. - STAMPA. - 112:1-2(2013), pp. 33-43. [10.1016/j.pbiomolbio.2013.03.019]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/696464
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