Hedgehog is a key morphogen regulating embryonic development and tissue repair. Remarkably, when misregulated, it leads to tumorigenesis. Hedgehog signaling is triggered by binding of ligands with transmembrane receptor Ptch and is subsequently mediated by transcriptional effectors belonging to the Gli family, whose functions is tuned by a number of molecular interactions and post-synthetic modifications. The complex of these regulatory circuitries provides a tight control of developmental processes, mainly involving the modulation of genes determining the fate of stem cells. Similarly, Hedgehog regulates cancer stem cells fostering tumorigenesis. To this regard, these processes represent promising targets for novel therapeutic strategies aiming at the control of stemness reactivation and maintenance in cancer. (C) 2012 Elsevier Inc. All rights reserved.

Control of stem cells and cancer stem cells by Hedgehog signaling: Pharmacologic clues from pathway dissection / Coni, Sonia; Infante, Paola; Gulino, Alberto. - In: BIOCHEMICAL PHARMACOLOGY. - ISSN 0006-2952. - 85:5(2013), pp. 623-628. [10.1016/j.bcp.2012.11.001]

Control of stem cells and cancer stem cells by Hedgehog signaling: Pharmacologic clues from pathway dissection

CONI, SONIA;INFANTE, PAOLA;GULINO, Alberto
2013

Abstract

Hedgehog is a key morphogen regulating embryonic development and tissue repair. Remarkably, when misregulated, it leads to tumorigenesis. Hedgehog signaling is triggered by binding of ligands with transmembrane receptor Ptch and is subsequently mediated by transcriptional effectors belonging to the Gli family, whose functions is tuned by a number of molecular interactions and post-synthetic modifications. The complex of these regulatory circuitries provides a tight control of developmental processes, mainly involving the modulation of genes determining the fate of stem cells. Similarly, Hedgehog regulates cancer stem cells fostering tumorigenesis. To this regard, these processes represent promising targets for novel therapeutic strategies aiming at the control of stemness reactivation and maintenance in cancer. (C) 2012 Elsevier Inc. All rights reserved.
2013
trans-activators; hedgehog proteins; hedgehog; gli-antagonists; neoplastic; smo-antagonists; neoplastic stem cells; transcription factors; humans; signal transduction; gene expression regulation; genetics/metabolism; oncogene proteins; stem cell; physiology; gli; cancer
01 Pubblicazione su rivista::01a Articolo in rivista
Control of stem cells and cancer stem cells by Hedgehog signaling: Pharmacologic clues from pathway dissection / Coni, Sonia; Infante, Paola; Gulino, Alberto. - In: BIOCHEMICAL PHARMACOLOGY. - ISSN 0006-2952. - 85:5(2013), pp. 623-628. [10.1016/j.bcp.2012.11.001]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/695912
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