We investigated the mechanism whereby expression of a transgene encoding a locally acting isoform of insulin-like growth factor 1 (mIGF-1) enhances repair of skeletal muscle damage. increased recruitment of proliferating bone marrow cells to injured MLC/ mIgf-1 transgenic muscles was accompanied by elevated bone marrow stem cell production in response to distal trauma. Regenerating MLC/mIgf-1 transgenic muscles contained increased cell populations expressing stem cell markers, exhibited accelerated myogenic differentiation, expressed markers of regeneration and readily converted cocultured bone marrow to muscle. These data implicate mIGF-1 as a powerful enhancer of the regeneration response, mediating the recruitment of bone marrow cells to sites of tissue damage and augmenting local repair mechanisms.

Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1 / Musaro, A; Giacinti, C; Borsellino, G; Dobrowolny, G; Pelosi, L; Cairns, L; Ottolenghi, S; Cossu, G; Bernardi, G; Battistini, L; M., Molinaro; Rosenthal, N.. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - 101:(2004), pp. 1206-1210. [10.1073/pnas.0303792101]

Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1

MUSARO A;GIACINTI C;DOBROWOLNY G;PELOSI L;
2004

Abstract

We investigated the mechanism whereby expression of a transgene encoding a locally acting isoform of insulin-like growth factor 1 (mIGF-1) enhances repair of skeletal muscle damage. increased recruitment of proliferating bone marrow cells to injured MLC/ mIgf-1 transgenic muscles was accompanied by elevated bone marrow stem cell production in response to distal trauma. Regenerating MLC/mIgf-1 transgenic muscles contained increased cell populations expressing stem cell markers, exhibited accelerated myogenic differentiation, expressed markers of regeneration and readily converted cocultured bone marrow to muscle. These data implicate mIGF-1 as a powerful enhancer of the regeneration response, mediating the recruitment of bone marrow cells to sites of tissue damage and augmenting local repair mechanisms.
2004
stem cells; muscle regeneration; IGF-1
01 Pubblicazione su rivista::01a Articolo in rivista
Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1 / Musaro, A; Giacinti, C; Borsellino, G; Dobrowolny, G; Pelosi, L; Cairns, L; Ottolenghi, S; Cossu, G; Bernardi, G; Battistini, L; M., Molinaro; Rosenthal, N.. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - 101:(2004), pp. 1206-1210. [10.1073/pnas.0303792101]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/6955
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