The authors carried out an ophthalmologic and dermatologic study of 60 patients. Thirty-five patients were affected with neurofibromatosis type 1 (NF1), where diagnosis was made by dermatologic parameters. Twenty-five were probands in whom no ophthalmologic signs of NF1 were observed. Iris (Lisch) nodules, which were present in 63% of all cases with NF1, had a direct relationship to age, reaching an incidence of 88% in patients older than age 40. The presence of Lisch nodules correlated with age and the presence of cutaneous neurofibromas, but not with cafe-au-lait spots and axillary/inguinal freckling.
Lisch nodules in neurofibromatosis type 1: Relationship to age and cutaneous neurofibromas / Recupero, S.M., Plateroti, R., Giustini, S., Abdolrahimzadeh, S., De Dominicis, M., Noviello, M.R., Calvieri, S.. - In: ANNALS OF OPHTHALMOLOGY-GLAUCOMA.. - ISSN 1079-4794. - STAMPA. - 28:3(1996), pp. 178-183.
Lisch nodules in neurofibromatosis type 1: Relationship to age and cutaneous neurofibromas
RECUPERO, Santi Maria;PLATEROTI, Rocco;GIUSTINI, Sandra;S. Abdolrahimzadeh;CALVIERI, Stefano
1996
Abstract
The authors carried out an ophthalmologic and dermatologic study of 60 patients. Thirty-five patients were affected with neurofibromatosis type 1 (NF1), where diagnosis was made by dermatologic parameters. Twenty-five were probands in whom no ophthalmologic signs of NF1 were observed. Iris (Lisch) nodules, which were present in 63% of all cases with NF1, had a direct relationship to age, reaching an incidence of 88% in patients older than age 40. The presence of Lisch nodules correlated with age and the presence of cutaneous neurofibromas, but not with cafe-au-lait spots and axillary/inguinal freckling.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
