Background. Chronic Venous Insufficiency (CVI) provokes skin pigmentation commonly seen in the gaiter region of the leg. The exact nature and pathogenesis of this are poorly understood. Objective. To evaluate the presence of melanin and haemosiderin in histological sections of the skin of limbs with primary varicose veins. Methods. Histological investigations were performed in 49 biopsies from pigmented and non-pigmented skin of limbs with varicose veins and control limbs. Results. All samples from pigmented skin showed a higher content Of melanin than controls. In contrast, haemosiderin was found in only a few biopsies taken from the more severely pigmented skin in areas of lipodermatosclerosis. Erythrocyte diapedesis was observed only where an intense inflammatory process was also present. Conclusions. Our findings suggest that in the initial phases of skin changes due to venous disease, pigmentation is attributable to melanin. Haemosiderin seems to play a role in the evolution of skin changes toward lipodermatosclerosis and ulceration. Erythrocyte diapedesis is likely to occur only during acute phases of the inflammatory process. Further investigations are needed to explain the cause and the exact cellular and molecular mechanisms responsible for hypermelanisation occurring in early phases of skin changes in CVI. (C) 2007 Published by Elsevier Ltd on behalf of European Society for Vascular Surgery.

The nature of skin pigmentations in chronic venous insufficiency: a preliminary report / Caggiati, Alberto; Caterina, Rosi; Franceschini, Marco; Innocenzi, Daniele. - In: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. - ISSN 1078-5884. - 35:1(2008), pp. 111-118. [10.1016/j.ejvs.2007.08.007]

The nature of skin pigmentations in chronic venous insufficiency: a preliminary report

CAGGIATI, Alberto
Primo
;
FRANCESCHINI, MARCO;INNOCENZI, Daniele
2008

Abstract

Background. Chronic Venous Insufficiency (CVI) provokes skin pigmentation commonly seen in the gaiter region of the leg. The exact nature and pathogenesis of this are poorly understood. Objective. To evaluate the presence of melanin and haemosiderin in histological sections of the skin of limbs with primary varicose veins. Methods. Histological investigations were performed in 49 biopsies from pigmented and non-pigmented skin of limbs with varicose veins and control limbs. Results. All samples from pigmented skin showed a higher content Of melanin than controls. In contrast, haemosiderin was found in only a few biopsies taken from the more severely pigmented skin in areas of lipodermatosclerosis. Erythrocyte diapedesis was observed only where an intense inflammatory process was also present. Conclusions. Our findings suggest that in the initial phases of skin changes due to venous disease, pigmentation is attributable to melanin. Haemosiderin seems to play a role in the evolution of skin changes toward lipodermatosclerosis and ulceration. Erythrocyte diapedesis is likely to occur only during acute phases of the inflammatory process. Further investigations are needed to explain the cause and the exact cellular and molecular mechanisms responsible for hypermelanisation occurring in early phases of skin changes in CVI. (C) 2007 Published by Elsevier Ltd on behalf of European Society for Vascular Surgery.
2008
chronic venous insufficiency; hemosiderin; melanin; stasis dermatitis; varicose veins
01 Pubblicazione su rivista::01a Articolo in rivista
The nature of skin pigmentations in chronic venous insufficiency: a preliminary report / Caggiati, Alberto; Caterina, Rosi; Franceschini, Marco; Innocenzi, Daniele. - In: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. - ISSN 1078-5884. - 35:1(2008), pp. 111-118. [10.1016/j.ejvs.2007.08.007]
File allegati a questo prodotto
File Dimensione Formato  
Caggiati_Nature_2008.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.67 MB
Formato Adobe PDF
1.67 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/69409
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 35
  • ???jsp.display-item.citation.isi??? 28
social impact