This study is aimed at characterizing molecular pathways common to neurodevelopment and neurodegeneration. Indeed, it is now evident that neurodegenerative processes can be rooted in aberrant expression of neurodevelopment-related genes. Among various genes, BDNF and reelin are good candidates as they play fundamental roles during brain development/maturation and adult functions and their expression is often altered in neurodegeneration. On the other hand, PSEN1, which is involved in A β processing, also plays crucial roles in the developing brain.
Complex expression of BDNF and reelin in the developing and adult brain of TgCRND8 mice / Fuso, Andrea; Nicolia, Vincenzina; Canterini, Sonia; Monti, Noemi; Ciraci, Viviana; Palladino, Giampiero; Cavallaro, ROSARIA ADELE; Fiorenza, Maria Teresa; Scarpa, Sigfrido. - STAMPA. - 9:(2013), pp. 357-357. (Intervento presentato al convegno AAIC tenutosi a Boston, United States nel 13th - 18th July) [10.1016/j.jalz.2013.05.678].
Complex expression of BDNF and reelin in the developing and adult brain of TgCRND8 mice
FUSO, ANDREA;NICOLIA, Vincenzina;CANTERINI, Sonia;Noemi Monti;CIRACI, VIVIANA;PALLADINO, GIAMPIERO;CAVALLARO, ROSARIA ADELE;FIORENZA, Maria Teresa;SCARPA, Sigfrido
2013
Abstract
This study is aimed at characterizing molecular pathways common to neurodevelopment and neurodegeneration. Indeed, it is now evident that neurodegenerative processes can be rooted in aberrant expression of neurodevelopment-related genes. Among various genes, BDNF and reelin are good candidates as they play fundamental roles during brain development/maturation and adult functions and their expression is often altered in neurodegeneration. On the other hand, PSEN1, which is involved in A β processing, also plays crucial roles in the developing brain.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
