Introduction: Bladder cancer ranks 4th overall in the number of newly diagnosed cancers and 10th in causes of cancer deaths. More than 90% of all cases of bladder cancer are transitional cell carcinoma (TCC). The goal of this study is to confirm the usefulness of low mechanical index contrast-enhanced ultrasonography (CEUS), also in association with time-intensity curves, in the differentiation between high- and low-grade bladder malignant lesions. Materials and methods: From February 2006 to February 2012 we recruited 144 patients. All patients underwent grayscale ultrasonography (US), color-Doppler ultrasonography (CDUS) and contrast-enhanced ultrasonography (CEUS). Subsequently all patients underwent cystoscopy and TURB. Results: Histological diagnoses were: 88 high-grade carcinomas (61.1%), and 56 low-grade carcinomas (38.9%). Sensitivity and specificity of CDUS were 87.5% (126/144) and 60%, respectively. Sensitivity and specificity of CEUS were 90.9% and 85.7%, respectively. Sensitivity and specificity of TIC were 91.6% (132/144) and 85.7%, respectively. Discussion and conclusions: CEUS is a reliable noninvasive method for differentiating low- and high-grade bladder carcinomas since it provides typical enhancement patterns as well as specific contrast-sonographic perfusion curves. © 2012 Elsevier Srl.

CEUS in the differentiation between low and high-grade bladder carcinoma / Drudi, Francesco Maria; DI LEO, Nicola; Malpassini, Flavio; F., Antonini; Corongiu, Emanuele; Iori, Francesco. - In: JOURNAL OF ULTRASOUND. - ISSN 1971-3495. - STAMPA. - 15:4(2012), pp. 247-251. [10.1016/j.jus.2012.09.002]

CEUS in the differentiation between low and high-grade bladder carcinoma

DRUDI, Francesco Maria;DI LEO, NICOLA;MALPASSINI, FLAVIO;CORONGIU, EMANUELE;IORI, Francesco
2012

Abstract

Introduction: Bladder cancer ranks 4th overall in the number of newly diagnosed cancers and 10th in causes of cancer deaths. More than 90% of all cases of bladder cancer are transitional cell carcinoma (TCC). The goal of this study is to confirm the usefulness of low mechanical index contrast-enhanced ultrasonography (CEUS), also in association with time-intensity curves, in the differentiation between high- and low-grade bladder malignant lesions. Materials and methods: From February 2006 to February 2012 we recruited 144 patients. All patients underwent grayscale ultrasonography (US), color-Doppler ultrasonography (CDUS) and contrast-enhanced ultrasonography (CEUS). Subsequently all patients underwent cystoscopy and TURB. Results: Histological diagnoses were: 88 high-grade carcinomas (61.1%), and 56 low-grade carcinomas (38.9%). Sensitivity and specificity of CDUS were 87.5% (126/144) and 60%, respectively. Sensitivity and specificity of CEUS were 90.9% and 85.7%, respectively. Sensitivity and specificity of TIC were 91.6% (132/144) and 85.7%, respectively. Discussion and conclusions: CEUS is a reliable noninvasive method for differentiating low- and high-grade bladder carcinomas since it provides typical enhancement patterns as well as specific contrast-sonographic perfusion curves. © 2012 Elsevier Srl.
2012
bladder cancer; contrast-enhanced ultrasonography; ceus; time-intensity curves; color-doppler ultrasonography; cdus
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CEUS in the differentiation between low and high-grade bladder carcinoma / Drudi, Francesco Maria; DI LEO, Nicola; Malpassini, Flavio; F., Antonini; Corongiu, Emanuele; Iori, Francesco. - In: JOURNAL OF ULTRASOUND. - ISSN 1971-3495. - STAMPA. - 15:4(2012), pp. 247-251. [10.1016/j.jus.2012.09.002]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/690877
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