A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site

Out of the active site binding pocket for carbonic anhydrase inhibitors / D'Ambrosio, K.; Carradori, S.; Monti, Sm; Buonanno, M.; Secci, Daniela; Vullo, D.; Supuran, Ct; De Simone, G.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 51:2(2015), pp. 302-305. [10.1039/c4cc07320g]

Out of the active site binding pocket for carbonic anhydrase inhibitors

SECCI, DANIELA;
2015

Abstract

A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site
2015
acesulfame; cancer-related isoforms; carbonic anhydrase inhibitor; N/O-substitution; saccharin
01 Pubblicazione su rivista::01a Articolo in rivista
Out of the active site binding pocket for carbonic anhydrase inhibitors / D'Ambrosio, K.; Carradori, S.; Monti, Sm; Buonanno, M.; Secci, Daniela; Vullo, D.; Supuran, Ct; De Simone, G.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 51:2(2015), pp. 302-305. [10.1039/c4cc07320g]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/684853
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