A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site
Out of the active site binding pocket for carbonic anhydrase inhibitors / D'Ambrosio, K.; Carradori, S.; Monti, Sm; Buonanno, M.; Secci, Daniela; Vullo, D.; Supuran, Ct; De Simone, G.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 51:2(2015), pp. 302-305. [10.1039/c4cc07320g]
Out of the active site binding pocket for carbonic anhydrase inhibitors
SECCI, DANIELA;
2015
Abstract
A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active siteFile allegati a questo prodotto
File | Dimensione | Formato | |
---|---|---|---|
D'Ambrosio_Out-of-the-active_2015.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
1.69 MB
Formato
Adobe PDF
|
1.69 MB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.