Sorbitol at 30% (w/w) stabilized human IgG to thermal denaturation from 60 to 85°C, increasing the protein's half life from 25 to 266 min at 70°C. A kinetic model based on the Lumry-Eyring inactivation scheme was developed and used to estimate the apparent rate constant and activation energy.
Sorbitol-mediated stabilization of human IgG against thermal inactivation / F., Cioci; Lavecchia, Roberto. - In: BIOTECHNOLOGY TECHNIQUES. - ISSN 0951-208X. - 12:11(1998), pp. 855-858. [10.1023/a:1008839912640]
Sorbitol-mediated stabilization of human IgG against thermal inactivation
LAVECCHIA, Roberto
1998
Abstract
Sorbitol at 30% (w/w) stabilized human IgG to thermal denaturation from 60 to 85°C, increasing the protein's half life from 25 to 266 min at 70°C. A kinetic model based on the Lumry-Eyring inactivation scheme was developed and used to estimate the apparent rate constant and activation energy.File allegati a questo prodotto
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