Synemin, a type IV intermediate filament (IF) protein, forms a bridge between IFs and cellular membranes. As an A-kinase-anchoring protein, it also provides temporal and spatial targeting of protein kinase A (PKA). However, little is known about its functional roles in either process. To better understand its functions in muscle tissue, we generated synemin-deficient (Synm(-) (/-)) mice. Synm(-) (/-) mice displayed normal development and fertility but showed a mild degeneration and regeneration phenotype in myofibres and defects in sarcolemma membranes. Following mechanical overload, Synm(-) (/-) mice muscles showed a higher hypertrophic capacity with increased maximal force and fatigue resistance compared with control mice. At the molecular level, increased remodelling capacity was accompanied by decreased myostatin (also known as GDF8) and atrogin (also known as FBXO32) expression, and increased follistatin expression. Furthermore, the activity of muscle-mass control molecules (the P

Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy / Li, Z.; Parlakian, A.; Coletti, Dario; Alonso Martin, S.; Hourdé, C.; Joanne, P.; Gao Li, J.; Blanc, J.; Ferry, A; Paulin, D.; Xue, Z.; Agbulut, O.. - In: JOURNAL OF CELL SCIENCE. - ISSN 0021-9533. - STAMPA. - 21:127(2014), pp. 4589-4601. [10.1242/jcs.143164]

Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.

COLETTI, Dario;
2014

Abstract

Synemin, a type IV intermediate filament (IF) protein, forms a bridge between IFs and cellular membranes. As an A-kinase-anchoring protein, it also provides temporal and spatial targeting of protein kinase A (PKA). However, little is known about its functional roles in either process. To better understand its functions in muscle tissue, we generated synemin-deficient (Synm(-) (/-)) mice. Synm(-) (/-) mice displayed normal development and fertility but showed a mild degeneration and regeneration phenotype in myofibres and defects in sarcolemma membranes. Following mechanical overload, Synm(-) (/-) mice muscles showed a higher hypertrophic capacity with increased maximal force and fatigue resistance compared with control mice. At the molecular level, increased remodelling capacity was accompanied by decreased myostatin (also known as GDF8) and atrogin (also known as FBXO32) expression, and increased follistatin expression. Furthermore, the activity of muscle-mass control molecules (the P
2014
01 Pubblicazione su rivista::01a Articolo in rivista
Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy / Li, Z.; Parlakian, A.; Coletti, Dario; Alonso Martin, S.; Hourdé, C.; Joanne, P.; Gao Li, J.; Blanc, J.; Ferry, A; Paulin, D.; Xue, Z.; Agbulut, O.. - In: JOURNAL OF CELL SCIENCE. - ISSN 0021-9533. - STAMPA. - 21:127(2014), pp. 4589-4601. [10.1242/jcs.143164]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/675842
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