BACKGROUND AND PURPOSE: Ketogenesis is a physiological phenomenon due to starvation or a ketogenic diet (KD), a drastic restricted carbohydrate dietary regimen that induces lipid metabolism and ketone body synthesis. Two patients whose migraines disappeared only during, and not outside, cycles of very-low-calorie KD performed to reduce their weight were recently observed. To confirm our observation, in a dietitian clinical setting two parallel groups of migraineurs, one receiving a 1-month very-low-calorie KD prescription followed by a 5-month standard low-calorie diet (SD) and the other a 6-month SD, were followed. METHODS: Ninety-six overweight female migraineurs were enrolled in a diet clinic and blindly received a KD (n = 45) or an SD (n = 51) prescription. Mean monthly attack frequency, number of days with headaches and tablet intake were assessed before and 1, 2, 3 and 6 months after diet initiation. RESULTS: In the KD group, the baseline attack frequency (2.9 attacks per mont

Migraine improvement during short lasting ketogenesis. A proof-of-concept study / DI LORENZO, Cherubino; Coppola, Gianluca; G., Sirianni; G., Di Lorenzo; Bracaglia, Martina; D., Di Lenola; Alberto, Siracusano; P., Rossi; Pierelli, Francesco. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - STAMPA. - 22:1(2015), pp. 170-177. [10.1111/ene.12550]

Migraine improvement during short lasting ketogenesis. A proof-of-concept study

DI LORENZO, CHERUBINO;COPPOLA, GIANLUCA;BRACAGLIA, MARTINA;PIERELLI, Francesco
2015

Abstract

BACKGROUND AND PURPOSE: Ketogenesis is a physiological phenomenon due to starvation or a ketogenic diet (KD), a drastic restricted carbohydrate dietary regimen that induces lipid metabolism and ketone body synthesis. Two patients whose migraines disappeared only during, and not outside, cycles of very-low-calorie KD performed to reduce their weight were recently observed. To confirm our observation, in a dietitian clinical setting two parallel groups of migraineurs, one receiving a 1-month very-low-calorie KD prescription followed by a 5-month standard low-calorie diet (SD) and the other a 6-month SD, were followed. METHODS: Ninety-six overweight female migraineurs were enrolled in a diet clinic and blindly received a KD (n = 45) or an SD (n = 51) prescription. Mean monthly attack frequency, number of days with headaches and tablet intake were assessed before and 1, 2, 3 and 6 months after diet initiation. RESULTS: In the KD group, the baseline attack frequency (2.9 attacks per mont
2015
ketone bodies; migraine; very-low-calorie diet; ketogenesis; ketogenic diet
01 Pubblicazione su rivista::01a Articolo in rivista
Migraine improvement during short lasting ketogenesis. A proof-of-concept study / DI LORENZO, Cherubino; Coppola, Gianluca; G., Sirianni; G., Di Lorenzo; Bracaglia, Martina; D., Di Lenola; Alberto, Siracusano; P., Rossi; Pierelli, Francesco. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - STAMPA. - 22:1(2015), pp. 170-177. [10.1111/ene.12550]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/675306
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