Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry. In this brief critical review the uses and applications of this versatile polymeric molecule will be discussed.
Polyethylenimine In Medicinal Chemistry / Vicennati, Paola; Giuliano, Antonella; Ortaggi, Giancarlo; Masotti, Andrea. - In: CURRENT MEDICINAL CHEMISTRY. - ISSN 0929-8673. - STAMPA. - 15:(2008), pp. 2826-2839. [10.2174/092986708786242778]
Polyethylenimine In Medicinal Chemistry
VICENNATI, PAOLA;GIULIANO, ANTONELLA;ORTAGGI, Giancarlo;MASOTTI, ANDREA
2008
Abstract
Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry. In this brief critical review the uses and applications of this versatile polymeric molecule will be discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
