Bach1, among the genes encoded on chromosome 21, is a transcription repressor, which binds to antioxidant response elements of DNA thus inhibiting the transcription of specific genes involved in the cell stress response including heme oxygenase-1 (HO-1). HO-1 and its partner, biliverdin reductase-A (BVR-A), are upregulated in response to oxidative stress in order to protect cells against further damage. Since oxidative stress is an early event in Down syndrome (DS) and might contribute to the development of multiple deleterious DS phenotypes, including Alzheimer's disease (AD) pathology, we investigated the status of the Bach1/HO-1/BVR-A axis in DS and its possible implications for the development of AD. In the present study, we showed increased total Bach1 protein levels in the brain of all DS cases coupled with reduced induction of brain HO-1. Furthermore, increased oxidative stress could, on one hand, overcome the inhibitory effects of Bach1 and, on the other hand, promote BVR-A imp
Bach1 overexpression in down syndrome correlates with the alteration of the ho-1/bvr-a system: insights for transition to Alzheimer's disease / Di Domenico, Fabio; Pupo, Gilda; Mancuso, C; Barone, Eugenio; Paolini, F; Arena, Andrea; Blarzino, Carla; Schmitt, Fa; Head, E; Butterfield, Da; Perluigi, Marzia. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - (2015). [10.3233/JAD-141254]
Bach1 overexpression in down syndrome correlates with the alteration of the ho-1/bvr-a system: insights for transition to Alzheimer's disease
DI DOMENICO, FABIO;PUPO, GILDA;BARONE, EUGENIO;Paolini F;ARENA, ANDREA;BLARZINO, Carla;PERLUIGI, Marzia
2015
Abstract
Bach1, among the genes encoded on chromosome 21, is a transcription repressor, which binds to antioxidant response elements of DNA thus inhibiting the transcription of specific genes involved in the cell stress response including heme oxygenase-1 (HO-1). HO-1 and its partner, biliverdin reductase-A (BVR-A), are upregulated in response to oxidative stress in order to protect cells against further damage. Since oxidative stress is an early event in Down syndrome (DS) and might contribute to the development of multiple deleterious DS phenotypes, including Alzheimer's disease (AD) pathology, we investigated the status of the Bach1/HO-1/BVR-A axis in DS and its possible implications for the development of AD. In the present study, we showed increased total Bach1 protein levels in the brain of all DS cases coupled with reduced induction of brain HO-1. Furthermore, increased oxidative stress could, on one hand, overcome the inhibitory effects of Bach1 and, on the other hand, promote BVR-A impFile | Dimensione | Formato | |
---|---|---|---|
Di Domenico_Bach1_2015_postprint.pdf
accesso aperto
Tipologia:
Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza:
Creative commons
Dimensione
3.46 MB
Formato
Adobe PDF
|
3.46 MB | Adobe PDF | |
Di Domenico_Bach1_2015.pdf
solo gestori archivio
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
731.94 kB
Formato
Adobe PDF
|
731.94 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.