Aim: The aim of the study was to evaluate whether the apparent diffusion coefficient (ADC) provided by 3.0 Tesla diffusion-weighted imaging (3T DWI) varies with the prognostic factors 1(167 and grading in invasive breast cancer. Materials and Methods: Seventy-three patients with 75 invasive breast cancer lesions who had undergone 3.0 Tesla magnetic resonance imaging (MRI) for local staging were enrolled. All lesions were confirmed by histologic and immunohistochemical analysis. MRI included both dynamic contrast-enhanced and DWI sequences. ADC value was obtained for each lesion. Histologic tumor grade was established according to the Nottingham Grading System (NGS), while 1(167 expression was evaluated by MM1 clone IgG1 mouse anti-human monoclonal antibody. Patients were divided into the following groups: grade 1 (G1), grade 2 (G2), grade 1 plus grade 2 (G1+G2) and grade 3 (G3), and low Ki67 (<= 14%), intermediate Ki67 (15%-30%), and high Ki67 (>= 30%). ADC values were compared with the G and Ki67 groups. Statistical comparison was carried out using the Mann-Whitney U and the Kruskal-Wallis H test. Results: ADC values were significantly higher in G3 than in G1+G2 tumors; no significant difference was observed when G1, G2, and G3 were compared. There was no statistically significant correlation between ADC values and Ki67 percentage (p>0.05). Discussion: ADC values obtained on 3T DWI correlate with low (G1+G2) and high-grade (G3) invasive breast carcinomas. Conclusion: ADC may be a helpful tool for identifying high-grade invasive breast carcinoma.

Apparent diffusion coefficient on 3.0 Tesla magnetic resonance imaging and prognostic factors in breast cancer / DE FELICE, Carlo; Cipolla, Valentina; Guerrieri, Daniele; Santucci, Diana; Musella, Angela; Porfiri, Lucio Maria; Meggiorini, Maria Letizia. - In: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY. - ISSN 0392-2936. - ELETTRONICO. - 35:4(2014), pp. 408-414. [10.12892/ejgo24792014]

Apparent diffusion coefficient on 3.0 Tesla magnetic resonance imaging and prognostic factors in breast cancer

DE FELICE, Carlo;CIPOLLA, VALENTINA;GUERRIERI, DANIELE;SANTUCCI, DIANA;MUSELLA, ANGELA;PORFIRI, Lucio Maria;MEGGIORINI, Maria Letizia
2014

Abstract

Aim: The aim of the study was to evaluate whether the apparent diffusion coefficient (ADC) provided by 3.0 Tesla diffusion-weighted imaging (3T DWI) varies with the prognostic factors 1(167 and grading in invasive breast cancer. Materials and Methods: Seventy-three patients with 75 invasive breast cancer lesions who had undergone 3.0 Tesla magnetic resonance imaging (MRI) for local staging were enrolled. All lesions were confirmed by histologic and immunohistochemical analysis. MRI included both dynamic contrast-enhanced and DWI sequences. ADC value was obtained for each lesion. Histologic tumor grade was established according to the Nottingham Grading System (NGS), while 1(167 expression was evaluated by MM1 clone IgG1 mouse anti-human monoclonal antibody. Patients were divided into the following groups: grade 1 (G1), grade 2 (G2), grade 1 plus grade 2 (G1+G2) and grade 3 (G3), and low Ki67 (<= 14%), intermediate Ki67 (15%-30%), and high Ki67 (>= 30%). ADC values were compared with the G and Ki67 groups. Statistical comparison was carried out using the Mann-Whitney U and the Kruskal-Wallis H test. Results: ADC values were significantly higher in G3 than in G1+G2 tumors; no significant difference was observed when G1, G2, and G3 were compared. There was no statistically significant correlation between ADC values and Ki67 percentage (p>0.05). Discussion: ADC values obtained on 3T DWI correlate with low (G1+G2) and high-grade (G3) invasive breast carcinomas. Conclusion: ADC may be a helpful tool for identifying high-grade invasive breast carcinoma.
2014
invasive breast cancer; apparent diffusion coefficient; grading; ki67; diffusion-weighted imaging
01 Pubblicazione su rivista::01a Articolo in rivista
Apparent diffusion coefficient on 3.0 Tesla magnetic resonance imaging and prognostic factors in breast cancer / DE FELICE, Carlo; Cipolla, Valentina; Guerrieri, Daniele; Santucci, Diana; Musella, Angela; Porfiri, Lucio Maria; Meggiorini, Maria Letizia. - In: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY. - ISSN 0392-2936. - ELETTRONICO. - 35:4(2014), pp. 408-414. [10.12892/ejgo24792014]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/664615
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 19
social impact