This study analysed the sequence of HIV-1 pol gene derived from Zimbabwean infected patients. Sequence analysis, performed on 8 samples, revealed that sequences were classified as subtype C (n=5), subtype B (n=2) and CRF01-AE (n=1). Two patients, treated with a therapeutic regimen containing NRTI/NNRTI, harboured drug resistance mutations in HIV-1 DNA. Phylogenetic analysis performed on subtype C sequences showed that our strains were aggregated in different clusters depending on the country of origin.
Genetic analyses of HIV-1 pol sequences from Zimbabwean patients / Falasca, Francesca; C., Temperoni; Mazzuti, Laura; A., Lo Presti; M., Ciccozzi; E., Di Filippo; G., Iaiani; Taliani, Gloria; Turriziani, Ombretta. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 37:3(2014), pp. 377-381.
Genetic analyses of HIV-1 pol sequences from Zimbabwean patients
FALASCA, FRANCESCA;MAZZUTI, LAURA;TALIANI, Gloria;TURRIZIANI, Ombretta
2014
Abstract
This study analysed the sequence of HIV-1 pol gene derived from Zimbabwean infected patients. Sequence analysis, performed on 8 samples, revealed that sequences were classified as subtype C (n=5), subtype B (n=2) and CRF01-AE (n=1). Two patients, treated with a therapeutic regimen containing NRTI/NNRTI, harboured drug resistance mutations in HIV-1 DNA. Phylogenetic analysis performed on subtype C sequences showed that our strains were aggregated in different clusters depending on the country of origin.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
