The organocatalytic kinetic resolution of 4-substituted oxazinones has been optimised (selectivity factor S up to 98, chiral oxazinone ee values up to 99.6 % (1 a-g) and product ee values up to 90 % (3 a-g)) in a rational way by applying the Design of Experiments (DoE) approach. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Kinetic Resolution of Oxazinones: Rational Exploration of Chemical Space through the Design of Experiments / Renzi, Polyssena; Christel, Kronig; Armando, Carlone; Serap, Eroksuz; Berkessel, Albrecht; Bella, Marco. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 20:37(2014), pp. 11768-11775. [10.1002/chem.201402380]
Kinetic Resolution of Oxazinones: Rational Exploration of Chemical Space through the Design of Experiments
RENZI, POLYSSENA;BELLA, Marco
2014
Abstract
The organocatalytic kinetic resolution of 4-substituted oxazinones has been optimised (selectivity factor S up to 98, chiral oxazinone ee values up to 99.6 % (1 a-g) and product ee values up to 90 % (3 a-g)) in a rational way by applying the Design of Experiments (DoE) approach. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
