Histological and histomorphometric human results of HA-Beta-TCP 30/70 compared to three different biomaterials in maxillary sinus augmentation at 6 months: a preliminary report

Objective: The aim of this investigation was to examine the bone regenerative potential of a newly biphasic calcium phosphate ceramics (HA-β-TCP 30/70), by assessing histological and histomorphometric results of human specimens retrieved from sinuses augmented with HA-β- TCP 30/70, and comparing them to anorganic bovine bone (ABB), mineralized solvent- dehydrated bone allograft (MSDBA), and equine bone (EB), after a healing period of 6 mo nths . Materials and Methods: Four consecutive patients with edentulous atrophic posterior maxilla, were included in this report. A two-stage procedure was carried out for sinus augmentation with HA-β-TCP 30/70, ABB, MSDBA, and EB. After 6 months, specimens were retrieved at the time of implant placement and processed for histological and histomorphometric analyses. Results: At histological examination, all biomaterials were in close contact with the newly formed bone and showed the same pattern of bone formation; the grafted granules were sur- rounded by a bridge-like network of newly formed bone. A limited amount of ABB particles was partially covered by connective tissue. The histomorphometric analysis revealed 30.2% newly formed bone for Ha-β-TCP 30/70, 20.1% for ABB, 16.4% for MSDBA, 21.9% for EB. Conclusions: Within the limitations of the present investigation, these results support the suc- cessful use of HA-β-TCP 30/70 for sinus augmentation.