The cone-rod homeobox (CRX) is a gene that belongs to the member of the orthodenticle homeobox (Otx) family, with important function in development and differentiation of retinal and pineal cells. Moreover, CRX appears to be specifically expressed in pineal tumors and retinoblastomas. We performed an immunohistochemical study on 91 pediatric and adult central nervous system tumors, plus 2 normal brain samples. Our results demonstrated that CRX is expressed not only in pineal parenchymal tumors and retinoblastoma, but also in a some medulloblastomas and supratentorial primitive neuroectodermal tumors. None of the glial tumors screened were positive for CRX. In conclusion, CRX could be useful in surgical neuropathology for the differential diagnosis of pineal region tumors, in particular to discriminate pineal tumors from glial tumors.

Is CRX protein a useful marker in differential diagnosis of tumors of the pineal region? / Antonelli, Manila; Lauriola, Libero; Buttarelli, Francesca Romana; Giangaspero, Felice; Mariangela, Novello; Gianno, Francesca. - In: PEDIATRIC AND DEVELOPMENTAL PATHOLOGY. - ISSN 1093-5266. - ELETTRONICO. - 17:2(2014), pp. 85-88. [10.2350/13-06-1346-OA.1]

Is CRX protein a useful marker in differential diagnosis of tumors of the pineal region?

ANTONELLI, MANILA;BUTTARELLI, Francesca Romana;GIANGASPERO, FELICE;GIANNO, FRANCESCA
2014

Abstract

The cone-rod homeobox (CRX) is a gene that belongs to the member of the orthodenticle homeobox (Otx) family, with important function in development and differentiation of retinal and pineal cells. Moreover, CRX appears to be specifically expressed in pineal tumors and retinoblastomas. We performed an immunohistochemical study on 91 pediatric and adult central nervous system tumors, plus 2 normal brain samples. Our results demonstrated that CRX is expressed not only in pineal parenchymal tumors and retinoblastoma, but also in a some medulloblastomas and supratentorial primitive neuroectodermal tumors. None of the glial tumors screened were positive for CRX. In conclusion, CRX could be useful in surgical neuropathology for the differential diagnosis of pineal region tumors, in particular to discriminate pineal tumors from glial tumors.
2014
Crx protein; Pineal tumor; Pineoblastoma; Adolescent; Adult; Biomarkers; Brain Neoplasms; Child; Child, Preschool; Diagnosis, Differential; Homeodomain Proteins; Humans; Immunohistochemistry; Neuroectodermal Tumors, Primitive; Pineal Gland; Retina; Trans-Activators; Pediatrics, Perinatology and Child Health; 2734
01 Pubblicazione su rivista::01a Articolo in rivista
Is CRX protein a useful marker in differential diagnosis of tumors of the pineal region? / Antonelli, Manila; Lauriola, Libero; Buttarelli, Francesca Romana; Giangaspero, Felice; Mariangela, Novello; Gianno, Francesca. - In: PEDIATRIC AND DEVELOPMENTAL PATHOLOGY. - ISSN 1093-5266. - ELETTRONICO. - 17:2(2014), pp. 85-88. [10.2350/13-06-1346-OA.1]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/650065
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