To assess the efficacy and safety of conservative surgical approach for microinvasive cervical cancer with regards to cone margins status and lymph vascular space invasion (LVSI). This was a multicentre retrospective cohort study of 153 women diagnosed with microinvasive cervical cancer over a 10 years period (1993-2003). In conservatively-treated women (n=80), neither cancer mortality nor disease relapse after 184.5±20.5 months of follow-up was detected. Residual disease in women who underwent secondary surgery was significantly related to positive margins on the primary cone excision (p=0.005) while no correlation with LVSI emerged. Conization can represent the definitive treatment for stage IA1, if surgical margins are cancer-free, independently of LVSI. A conservative surgical approach could also be considered in women with IA2 cervical cancer when preservation of fertility is strongly requested. A close long-term surveillance should be scheduled for conservatively-treated women. Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
Surgical Approach and Long-term Clinical Outcome in Women with Microinvasive Cervical Cancer / F., Sopracordevole; G., Chiossi; M., Barbero; P., Cristoforoni; B., Ghiringhello; Frega, Antonio; F., Tortolani; Boselli F., Clemente; A., Italian Society Of Colposcopy Ciavattini; Cervico Vaginal, Pathology. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - STAMPA. - 34:8(2014), pp. 4345-4349.
Surgical Approach and Long-term Clinical Outcome in Women with Microinvasive Cervical Cancer.
FREGA, Antonio;
2014
Abstract
To assess the efficacy and safety of conservative surgical approach for microinvasive cervical cancer with regards to cone margins status and lymph vascular space invasion (LVSI). This was a multicentre retrospective cohort study of 153 women diagnosed with microinvasive cervical cancer over a 10 years period (1993-2003). In conservatively-treated women (n=80), neither cancer mortality nor disease relapse after 184.5±20.5 months of follow-up was detected. Residual disease in women who underwent secondary surgery was significantly related to positive margins on the primary cone excision (p=0.005) while no correlation with LVSI emerged. Conization can represent the definitive treatment for stage IA1, if surgical margins are cancer-free, independently of LVSI. A conservative surgical approach could also be considered in women with IA2 cervical cancer when preservation of fertility is strongly requested. A close long-term surveillance should be scheduled for conservatively-treated women. Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
