The Wnt pathway has an important role in bone formation. Inactivation of sclerostin, an inhibitor of this pathway, has been associated with increased bone mass both in animal experiments and in human clinical trials. Romosozumab is a humanized monoclonal antibody targeting sclerostin. Preclinical studies showed that this antibody primarily increases bone formation resulting in increased bone mineral density. Initial studies carried out in humans are in line with data obtained in animals. If these results are confirmed in larger studies with fracture end-points, this monoclonal antibody with its anabolic action, will become a key drug in the treatment of osteoporosis. © Informa UK, Ltd.

Romosozumab: From basic to clinical aspects / Minisola, Salvatore. - In: EXPERT OPINION ON BIOLOGICAL THERAPY. - ISSN 1471-2598. - STAMPA. - 14:9(2014), pp. 1225-1228. [10.1517/14712598.2014.920815]

Romosozumab: From basic to clinical aspects

MINISOLA, Salvatore
2014

Abstract

The Wnt pathway has an important role in bone formation. Inactivation of sclerostin, an inhibitor of this pathway, has been associated with increased bone mass both in animal experiments and in human clinical trials. Romosozumab is a humanized monoclonal antibody targeting sclerostin. Preclinical studies showed that this antibody primarily increases bone formation resulting in increased bone mineral density. Initial studies carried out in humans are in line with data obtained in animals. If these results are confirmed in larger studies with fracture end-points, this monoclonal antibody with its anabolic action, will become a key drug in the treatment of osteoporosis. © Informa UK, Ltd.
2014
anabolic therapy; osteoporosis; romosozumab; sclerostin
01 Pubblicazione su rivista::01a Articolo in rivista
Romosozumab: From basic to clinical aspects / Minisola, Salvatore. - In: EXPERT OPINION ON BIOLOGICAL THERAPY. - ISSN 1471-2598. - STAMPA. - 14:9(2014), pp. 1225-1228. [10.1517/14712598.2014.920815]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/649861
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