In response to injury, skeletal muscle has high capacity to regenerate: quiescent muscle progenitor cells begin to proliferate and express transcription factors for muscle specification. In vitro has been demonstrated that completion of muscle differentiation requires shuttling of histone deacetylase 4 (HDAC4), a member of class IIa HDACs, from the nucleus to the cytoplasm and consequent activation of MEF2-dependent differentiation genes. In vivo, HDAC4 expression is up-regulated in skeletal muscle upon injury and in muscular dystrophy, suggesting a role for this protein in muscle regeneration.
HDAC4 is necessary for satellite cell differentiation and muscle regeneration / Marroncelli, Nicoletta; Adamo, Sergio; Moresi, Viviana. - In: EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY. - ISSN 2037-7460. - ELETTRONICO. - 23:(2013), pp. 109-112. (Intervento presentato al convegno X Annual Meeting of the Interuniversity Institute of Myology tenutosi a Monteriggioni (SI) nel 10-13/10/2013) [10.4081/bam.2013.3.2].
HDAC4 is necessary for satellite cell differentiation and muscle regeneration
MARRONCELLI, NICOLETTA;ADAMO, Sergio;MORESI, Viviana
2013
Abstract
In response to injury, skeletal muscle has high capacity to regenerate: quiescent muscle progenitor cells begin to proliferate and express transcription factors for muscle specification. In vitro has been demonstrated that completion of muscle differentiation requires shuttling of histone deacetylase 4 (HDAC4), a member of class IIa HDACs, from the nucleus to the cytoplasm and consequent activation of MEF2-dependent differentiation genes. In vivo, HDAC4 expression is up-regulated in skeletal muscle upon injury and in muscular dystrophy, suggesting a role for this protein in muscle regeneration.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
