Modulation of specific gene response following physiological and pathological signaling require multiple levels of transcriptional control. In response to injury, skeletal muscle exhibits high capacity to regenerate and epigenetics controls multiple steps of this process. In vitro has been demonstrated that completion of muscle differentiation requires shuttling of histone deacetylase 4 (HDAC4), a member of class IIa HDACs, from the nucleus to the cytoplasm and consequent activation of MEF2-dependent differentiation genes.
HDAC4 is necessary for satellite cell differentiation and muscle regeneration / Marroncelli, Nicoletta; C., Noviello; S., Consalvi; V., Saccone; P. L., Puri; E. N., Olson; Adamo, Sergio; Moresi, Viviana. - ELETTRONICO. - (2014). (Intervento presentato al convegno EMBO Conference Molecular Biology of Muscle Development and Regeneration tenutosi a Acaya (LE) nel 14 – 18 May 2014).
HDAC4 is necessary for satellite cell differentiation and muscle regeneration
MARRONCELLI, NICOLETTA;ADAMO, Sergio;MORESI, Viviana
2014
Abstract
Modulation of specific gene response following physiological and pathological signaling require multiple levels of transcriptional control. In response to injury, skeletal muscle exhibits high capacity to regenerate and epigenetics controls multiple steps of this process. In vitro has been demonstrated that completion of muscle differentiation requires shuttling of histone deacetylase 4 (HDAC4), a member of class IIa HDACs, from the nucleus to the cytoplasm and consequent activation of MEF2-dependent differentiation genes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
