In response to injury, skeletal muscle exhibits high capacity to regenerate and epigenetics controls multiple steps of this process (Giordani et al., 2013). It has been demonstrated in vitro that completion of muscle differentiation requires shuttling of histone deacetylase 4 (HDAC4), a member of class IIa HDACs, from the nucleus to the cytoplasm and consequent activation of MEF2-dependent differentiation genes (McKinsey et al., 2000). In vivo, HDAC4 expression is up-regulated in skeletal muscle upon injury, suggesting a role for this protein in muscle regeneration
HDAC4 is necessary for satellite cell differentiation and muscle regeneration / Marroncelli, Nicoletta; C., Noviello; S., Consalvi; V., Saccone; P. L., Puri; E. N., Olson; Adamo, Sergio; Moresi, Viviana. - In: ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY. - ISSN 1122-6714. - STAMPA. - 119:(2014), pp. 126-126. (Intervento presentato al convegno 68° Congresso Nazionale SIAI tenutosi a Ancona nel 18-20/09/2014) [10.13128/IJAE-15965].
HDAC4 is necessary for satellite cell differentiation and muscle regeneration
MARRONCELLI, NICOLETTA;ADAMO, Sergio;MORESI, Viviana
2014
Abstract
In response to injury, skeletal muscle exhibits high capacity to regenerate and epigenetics controls multiple steps of this process (Giordani et al., 2013). It has been demonstrated in vitro that completion of muscle differentiation requires shuttling of histone deacetylase 4 (HDAC4), a member of class IIa HDACs, from the nucleus to the cytoplasm and consequent activation of MEF2-dependent differentiation genes (McKinsey et al., 2000). In vivo, HDAC4 expression is up-regulated in skeletal muscle upon injury, suggesting a role for this protein in muscle regenerationI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
