In a retrospective observational study, we evaluated the feasibility and safety of medical therapy with transabdominal ultrasound-guided injection of methotrexate (MTX) into the gestational sac (GS) in patients with interstitial ectopic pregnancies. Fourteen interstitial ectopic pregnancies were treated with transabdominal ultrasound-guided injection of MTX (25 mg). All patients were hemodynamically stable. In all patients, the 10-cm distance between the GS and vaginal fornices was ≥10 cm, making transvaginal injection difficult. To evaluate feasibility and safety of the procedure, we assessed complications clinically and with imaging during a 1-year follow-up. In all 14 patients, MTX injected locally into the GS successfully terminated the interstitial pregnancy, thereby avoiding surgery. There was no complications during follow-up. The successful outcome in our patients suggests that the transabdominal route is feasible and safe as a nonsurgical option for terminating an ectopic interstitial pregnancy in patients in whom the transvaginal route is contraindicated or difficult, provided the patients are properly selected and operators have sufficient experience with the technique. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound, 2014. Copyright © 2014 Wiley Periodicals, Inc.

Transabdominal ultrasound-guided injection of methotrexate in the treatment of ectopic interstitial pregnancies / FRAMARINO DEI MALATESTA, Marialuisa; Piccioni, Maria Grazia; Derme, Martina; Nicoletta Fabiana, Polidori; Valentina, Tibaldi; Iannini, Isabella; Gabriele, Masselli. - In: JOURNAL OF CLINICAL ULTRASOUND. - ISSN 0091-2751. - STAMPA. - 42:9(2014), pp. n/a-n/a. [10.1002/jcu.22185]

Transabdominal ultrasound-guided injection of methotrexate in the treatment of ectopic interstitial pregnancies.

FRAMARINO DEI MALATESTA, Marialuisa;PICCIONI, Maria Grazia;DERME, MARTINA;IANNINI, ISABELLA;
2014

Abstract

In a retrospective observational study, we evaluated the feasibility and safety of medical therapy with transabdominal ultrasound-guided injection of methotrexate (MTX) into the gestational sac (GS) in patients with interstitial ectopic pregnancies. Fourteen interstitial ectopic pregnancies were treated with transabdominal ultrasound-guided injection of MTX (25 mg). All patients were hemodynamically stable. In all patients, the 10-cm distance between the GS and vaginal fornices was ≥10 cm, making transvaginal injection difficult. To evaluate feasibility and safety of the procedure, we assessed complications clinically and with imaging during a 1-year follow-up. In all 14 patients, MTX injected locally into the GS successfully terminated the interstitial pregnancy, thereby avoiding surgery. There was no complications during follow-up. The successful outcome in our patients suggests that the transabdominal route is feasible and safe as a nonsurgical option for terminating an ectopic interstitial pregnancy in patients in whom the transvaginal route is contraindicated or difficult, provided the patients are properly selected and operators have sufficient experience with the technique. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound, 2014. Copyright © 2014 Wiley Periodicals, Inc.
2014
interstitial pregnancy; ultrasound; obstetrics; ectopic pregnancy; methotrexate
01 Pubblicazione su rivista::01a Articolo in rivista
Transabdominal ultrasound-guided injection of methotrexate in the treatment of ectopic interstitial pregnancies / FRAMARINO DEI MALATESTA, Marialuisa; Piccioni, Maria Grazia; Derme, Martina; Nicoletta Fabiana, Polidori; Valentina, Tibaldi; Iannini, Isabella; Gabriele, Masselli. - In: JOURNAL OF CLINICAL ULTRASOUND. - ISSN 0091-2751. - STAMPA. - 42:9(2014), pp. n/a-n/a. [10.1002/jcu.22185]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/649001
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