RESVERATROL-INDUCED AUTOPHAGY CONTRIBUTES TO THE INHIBITION OF EPSTEIN BARR VIRUS REPLICATION IN BURKITT’S LYMPHOMA CELLS De Leo Alessandra (a), Colavita Francesca (a), Arena Giuseppe (b), Mattia Elena (a) (a) Dip. di Scienze di Sanità Pubblica e Malattie Infettive “Sanarelli”, Univ. di Roma “Sapienza” (b) Casa Sollievo della Sofferenza Hospital, CSS-Mendel Institute, Roma Presenting author: De Leo Alessandra, Alessandra.Deleo@uniroma1.it We have previously examined the antiviral activity of resveratrol on the replication of Epstein Barr Virus (EBV), the etiologic agent of infectious mononucleosis and associated with several types of malignancies of epithelial and lymphoid origin. In a cellular context that allows in vitro EBV activation and lytic cycle progression through mechanisms closely resembling those that in vivo initiate and enable productive infection, we found that RV inhibited EBV lytic genes expression and the production of viral particles in a dose-dependent manner.
RESVERATROL-INDUCED AUTOPHAGY CONTRIBUTES TO THE INHIBITION OF EPSTEIN BARR VIRUS REPLICATION IN BURKITT’S LYMPHOMA CELLS / DE LEO, Alessandra; F., Colavita; G., Arena; Mattia, Elena. - (2013). (Intervento presentato al convegno Fifth ARTOI international Congress tenutosi a ISS Roma nel 6-7 novembre 2013).
RESVERATROL-INDUCED AUTOPHAGY CONTRIBUTES TO THE INHIBITION OF EPSTEIN BARR VIRUS REPLICATION IN BURKITT’S LYMPHOMA CELLS
DE LEO, ALESSANDRA;MATTIA, Elena
2013
Abstract
RESVERATROL-INDUCED AUTOPHAGY CONTRIBUTES TO THE INHIBITION OF EPSTEIN BARR VIRUS REPLICATION IN BURKITT’S LYMPHOMA CELLS De Leo Alessandra (a), Colavita Francesca (a), Arena Giuseppe (b), Mattia Elena (a) (a) Dip. di Scienze di Sanità Pubblica e Malattie Infettive “Sanarelli”, Univ. di Roma “Sapienza” (b) Casa Sollievo della Sofferenza Hospital, CSS-Mendel Institute, Roma Presenting author: De Leo Alessandra, Alessandra.Deleo@uniroma1.it We have previously examined the antiviral activity of resveratrol on the replication of Epstein Barr Virus (EBV), the etiologic agent of infectious mononucleosis and associated with several types of malignancies of epithelial and lymphoid origin. In a cellular context that allows in vitro EBV activation and lytic cycle progression through mechanisms closely resembling those that in vivo initiate and enable productive infection, we found that RV inhibited EBV lytic genes expression and the production of viral particles in a dose-dependent manner.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
