INHIBITION OF EPSTEIN BARR VIRUS REPLICATION BY RESVERATROL Resveratrol (trans-3,4’,5 trihydroxy-stilbene), a polyphenolic phytoalexin produced by a variety of plants, has gained considerable attention as cancer chemopreventive agent and to control fungal, bacterial and viral infections. We have recently shown that resveratrol is able to induce apoptosis of EBV infected Burkitt’s lymphoma cells with an efficacy inversely related to the restriction pattern of viral latent gene expression (De Leo et al., 2011). The anti-viral activity of resveratrol has been reported for several members of the Herpesviridae family, HIV, influenza A virus and polyomavirus (Campagna and Rivas, 2010). In these studies, we have examined the effects of resveratrol on EBV replication in Burkitt’s lymphoma cells treated with different compounds that allow EBV lytic cycle induction. We found that, independently of the method used to trigger EBV activation, resveratrol strongly inhibited lytic cycle initiation
Inhibition of Epstein Barr Vurus Replication by resveratrol / DE LEO, Alessandra; G., Arena; E., Lacanna; G., Oliviero; F., Colavita; Mattia, Elena. - STAMPA. - (2012), pp. 35-35. (Intervento presentato al convegno International Congress on oncogenic herpesviruses and associated diseases tenutosi a Philadelphia nel 1-4 Agosto 2012).
Inhibition of Epstein Barr Vurus Replication by resveratrol
DE LEO, ALESSANDRA;MATTIA, Elena
2012
Abstract
INHIBITION OF EPSTEIN BARR VIRUS REPLICATION BY RESVERATROL Resveratrol (trans-3,4’,5 trihydroxy-stilbene), a polyphenolic phytoalexin produced by a variety of plants, has gained considerable attention as cancer chemopreventive agent and to control fungal, bacterial and viral infections. We have recently shown that resveratrol is able to induce apoptosis of EBV infected Burkitt’s lymphoma cells with an efficacy inversely related to the restriction pattern of viral latent gene expression (De Leo et al., 2011). The anti-viral activity of resveratrol has been reported for several members of the Herpesviridae family, HIV, influenza A virus and polyomavirus (Campagna and Rivas, 2010). In these studies, we have examined the effects of resveratrol on EBV replication in Burkitt’s lymphoma cells treated with different compounds that allow EBV lytic cycle induction. We found that, independently of the method used to trigger EBV activation, resveratrol strongly inhibited lytic cycle initiationI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
