The KIAA1549:BRAF fusion gene is considered a driver genetic event in pilocytic astrocytoma. We investigated a series of 69 pediatric brain neoplasms of diverse histogenesis and grade using the RT-PCR and sequencing. We detected the KIAA1549:BRAF fusion gene in five of 34 non-PA tumors (14.7%), that is, one glioblastoma, one anaplastic astrocytoma, one anaplastic pleomorphic xanthoastrocytoma, 1 ependymoma, and 1 Atypical Teratoid Rhabdoid Tumor. Our study showed that the K-B, although uncommon, it can be detected in non-PA tumors of various histogenesis and grading. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.

KIAA1549:BRAF fusion gene in pediatric brain tumors of various histogenesis / Antonelli, Manila; Badiali, M; Moi, L; Buttarelli, Francesca Romana; Baldi, Caterina; Massimino, M; Sanson, M; Giangaspero, Felice. - In: PEDIATRIC BLOOD & CANCER. - ISSN 1545-5009. - STAMPA. - 62:4(2015), pp. 724-727. [10.1002/pbc.25272]

KIAA1549:BRAF fusion gene in pediatric brain tumors of various histogenesis

ANTONELLI, MANILA
Primo
;
Badiali M
Secondo
;
BUTTARELLI, Francesca Romana;BALDI, CATERINA;GIANGASPERO, FELICE
Ultimo
2015

Abstract

The KIAA1549:BRAF fusion gene is considered a driver genetic event in pilocytic astrocytoma. We investigated a series of 69 pediatric brain neoplasms of diverse histogenesis and grade using the RT-PCR and sequencing. We detected the KIAA1549:BRAF fusion gene in five of 34 non-PA tumors (14.7%), that is, one glioblastoma, one anaplastic astrocytoma, one anaplastic pleomorphic xanthoastrocytoma, 1 ependymoma, and 1 Atypical Teratoid Rhabdoid Tumor. Our study showed that the K-B, although uncommon, it can be detected in non-PA tumors of various histogenesis and grading. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
2015
pilocytic astrocytoma; kia1549; braf
01 Pubblicazione su rivista::01a Articolo in rivista
KIAA1549:BRAF fusion gene in pediatric brain tumors of various histogenesis / Antonelli, Manila; Badiali, M; Moi, L; Buttarelli, Francesca Romana; Baldi, Caterina; Massimino, M; Sanson, M; Giangaspero, Felice. - In: PEDIATRIC BLOOD & CANCER. - ISSN 1545-5009. - STAMPA. - 62:4(2015), pp. 724-727. [10.1002/pbc.25272]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/636989
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