Introduction: to assess the role of systemic therapy with fluoroquinolones in patients with diplopia after retinal detachment surgery, considering the effects of these antibiotics on tendons and muscles as evidenced in literature. Methods or Study Design: 30 patients with diplopia after retinal detachment surgery (P group) and 30 patients without diplopia after surgery (N group) were examined retrospectively. Systemic and ocular conditions, systemic and ocular therapy, type of surgical procedures, refraction and visual acuity before and after surgery, type of diplopia were evaluated. The survey has been particularly concerned with the type of antibiotic and steroid systemic therapy administered, the duration of both therapies and the appearance of diplopia according to the time of administration. Statistical analysis: Chi-squared Test, Anova one way and Mann- Whitney test. In addition, we examined the Odds Ratio (OR), the Confidence interval (CI) and we considered as significative p values = 0.004. Results: The risk of diplopia after retinal detachment surgery is associated with fluoroquinolones and macrolides therapy. 11 patients of the P group and 3 of the N group underwent administration of fluoroquinolones, while 7 patients in the P group and 1 patient in the N group took macrolides. The Odds Ratio in these patients was 9.5 (CI} 95%, range 1.6–62), so the risk of developing diplopia was eight times higher in the P group than in the N group. Patients in the P group presented an early appearance of diplopia; they also showed a longer period of antibiotic and steroid therapy than those in N group (8.9 days vs 4.9 days for systemic antibiotic therapy, 19.5 days vs 6.9 days for systemic steroid therapy). Conclusions: Diplopia after retinal detachment surgery can be related not only to the kind of surgical procedure, but also to the systemic administration of fluoroquinolones or macrolides and to the period of antibiotic therapy.
Role of Fluoroquinolones in Diplopia After Retinal Detachment Surgery / Arrico, Loredana; C., Ganino; S., Bianchi; R., Giannotti; Malagola, Romualdo. - In: OPHTHALMOLOGICA. - ISSN 0030-3755. - STAMPA. - 232 - Suppl. 2:(2014), pp. 37-37. (Intervento presentato al convegno 14th ESASO Retina Academy tenutosi a Istanbul, Turkey nel November 13-15, 2014) [10.1159/000368726].
Role of Fluoroquinolones in Diplopia After Retinal Detachment Surgery
ARRICO, Loredana;MALAGOLA, Romualdo
2014
Abstract
Introduction: to assess the role of systemic therapy with fluoroquinolones in patients with diplopia after retinal detachment surgery, considering the effects of these antibiotics on tendons and muscles as evidenced in literature. Methods or Study Design: 30 patients with diplopia after retinal detachment surgery (P group) and 30 patients without diplopia after surgery (N group) were examined retrospectively. Systemic and ocular conditions, systemic and ocular therapy, type of surgical procedures, refraction and visual acuity before and after surgery, type of diplopia were evaluated. The survey has been particularly concerned with the type of antibiotic and steroid systemic therapy administered, the duration of both therapies and the appearance of diplopia according to the time of administration. Statistical analysis: Chi-squared Test, Anova one way and Mann- Whitney test. In addition, we examined the Odds Ratio (OR), the Confidence interval (CI) and we considered as significative p values = 0.004. Results: The risk of diplopia after retinal detachment surgery is associated with fluoroquinolones and macrolides therapy. 11 patients of the P group and 3 of the N group underwent administration of fluoroquinolones, while 7 patients in the P group and 1 patient in the N group took macrolides. The Odds Ratio in these patients was 9.5 (CI} 95%, range 1.6–62), so the risk of developing diplopia was eight times higher in the P group than in the N group. Patients in the P group presented an early appearance of diplopia; they also showed a longer period of antibiotic and steroid therapy than those in N group (8.9 days vs 4.9 days for systemic antibiotic therapy, 19.5 days vs 6.9 days for systemic steroid therapy). Conclusions: Diplopia after retinal detachment surgery can be related not only to the kind of surgical procedure, but also to the systemic administration of fluoroquinolones or macrolides and to the period of antibiotic therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.