Context: Interplay between adipose tissue and adrenal glands has been recently suggested, without well-founded actions of locally adipose tissue surrounding the adrenal glands. Objective: We hypothesized that the local expression of leptin and adiponectin can be associated with pathological changes of the adrenal glands. Patients and main outcome measures: we evaluated RT-PCR of leptin and adiponectin mRNA expression from the adipose tissue surrounding adrenal glands in 30 patients, collecting adipose tissue surrounding the adrenal neoplasms, peri-renal and subcutaneous depots. Results: Leptin mRNA levels from adrenal neoplasia and peri-renal fat were significantly higher in aldosterone-producing adenoma (APA) than in non-functioning adenomas (NFA) (p<0.001 and p<0.02, respectively). In patients with Cushing's syndrome (CS) leptin mRNA levels were significantly higher in adrenal fat than in peri-renal (p<0.05) and subcutaneous adipose tissue (p<0.001). Adiponectin mRNA expression from

Leptin and adiponectin mRNA expression from the adipose tissue surrounding the adrenal neoplasia / Letizia, Claudio; Petramala, Luigi; Di Gioia, Cira Rosaria Tiziana; Chiappetta, Caterina; Zinnamosca, Laura; Marinelli, Cristiano; Iannucci, Gino; Ciardi, Antonio; De Toma, Giorgio; Iacobellis, G.. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. - ISSN 1945-7197. - 100:1(2015), pp. E101-E104. [10.1210/jc.2014-2274]

Leptin and adiponectin mRNA expression from the adipose tissue surrounding the adrenal neoplasia

LETIZIA, Claudio
Primo
;
PETRAMALA, LUIGI
Secondo
;
DI GIOIA, Cira Rosaria Tiziana;CHIAPPETTA, CATERINA;ZINNAMOSCA, LAURA;MARINELLI, CRISTIANO;IANNUCCI, Gino;CIARDI, Antonio;DE TOMA, Giorgio
Penultimo
;
2015

Abstract

Context: Interplay between adipose tissue and adrenal glands has been recently suggested, without well-founded actions of locally adipose tissue surrounding the adrenal glands. Objective: We hypothesized that the local expression of leptin and adiponectin can be associated with pathological changes of the adrenal glands. Patients and main outcome measures: we evaluated RT-PCR of leptin and adiponectin mRNA expression from the adipose tissue surrounding adrenal glands in 30 patients, collecting adipose tissue surrounding the adrenal neoplasms, peri-renal and subcutaneous depots. Results: Leptin mRNA levels from adrenal neoplasia and peri-renal fat were significantly higher in aldosterone-producing adenoma (APA) than in non-functioning adenomas (NFA) (p<0.001 and p<0.02, respectively). In patients with Cushing's syndrome (CS) leptin mRNA levels were significantly higher in adrenal fat than in peri-renal (p<0.05) and subcutaneous adipose tissue (p<0.001). Adiponectin mRNA expression from
2015
Adipose tissue; adrenal glands; mRNA
01 Pubblicazione su rivista::01a Articolo in rivista
Leptin and adiponectin mRNA expression from the adipose tissue surrounding the adrenal neoplasia / Letizia, Claudio; Petramala, Luigi; Di Gioia, Cira Rosaria Tiziana; Chiappetta, Caterina; Zinnamosca, Laura; Marinelli, Cristiano; Iannucci, Gino; Ciardi, Antonio; De Toma, Giorgio; Iacobellis, G.. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. - ISSN 1945-7197. - 100:1(2015), pp. E101-E104. [10.1210/jc.2014-2274]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/630175
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