Background: The outcome of benign convulsions associated with gastroenteritis (CwG) has generally been reported as being excellent. However, these data need to be confirmed in studies with longer follow-up evaluations. Aim: To assess the long-term neurological outcome of a large sample of children presenting with CwG. Methods: We reviewed clinical features of 81 subjects presenting with CwG (1994-2010) from three different Italian centers with a follow-up period of at least 3 years. Results: Follow-up period ranged from 39 months to 15 years (mean 9.8 years). Neurological examination and cognitive level at the last evaluation were normal in all the patients. A mild attention deficit was detected in three cases (3.7%). Fourteen children (17.3%) received chronic anti-epileptic therapy. Interictal EEG abnormalities detected at onset in 20 patients (24.7%) reverted to normal. Transient EEG epileptiform abnormalities were detected in other three cases (3.7%), and a transient photosensitivity in one (1.2%). No recurrence of CwG was observed. Three patients (3.7%) presented with a febrile seizure and two (2.5%) with an unprovoked seizure, but none developed epilepsy. Conclusions: The long-term evaluation of children with CwG confirms the excellent prognosis of this condition, with normal psychomotor development and low risk of relapse and of subsequent epilepsy.
Long-term follow-up in children with benign convulsions associated with gastroenteritis / Alberto, Verrotti; Romina, Moavero; Federico, Vigevano; Laura, Cantonetti; Azzurra, Guerra; Elisabetta, Spezia; Antonella, Tricarico; Giuliana, Nanni; Sergio, Agostinelli; Francesco, Chiarelli; Parisi, Pasquale; Giuseppe, Capovilla; Francesca, Beccaria; Spalice, Alberto; Giangennaro, Coppola; Emilio, Franzoni; Gentile Jr, V.; Susanna, Casellato; Pierangelo, Veggiotti; Sara, Malgesini; Giovanni, Crichiutti; Paolo, Balestri; Salvatore, Grosso; Nelia, Zamponi; Gemma, Incorpora; Salvatore, Savasta; Paola, Costa; Dario, Pruna; Raffaella, Cusmai. - In: EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY. - ISSN 1090-3798. - STAMPA. - 18:5(2014), pp. 572-577. [10.1016/j.ejpn.2014.04.006]
Long-term follow-up in children with benign convulsions associated with gastroenteritis
PARISI, PasqualeWriting – Review & Editing
;Alberto Spalice;
2014
Abstract
Background: The outcome of benign convulsions associated with gastroenteritis (CwG) has generally been reported as being excellent. However, these data need to be confirmed in studies with longer follow-up evaluations. Aim: To assess the long-term neurological outcome of a large sample of children presenting with CwG. Methods: We reviewed clinical features of 81 subjects presenting with CwG (1994-2010) from three different Italian centers with a follow-up period of at least 3 years. Results: Follow-up period ranged from 39 months to 15 years (mean 9.8 years). Neurological examination and cognitive level at the last evaluation were normal in all the patients. A mild attention deficit was detected in three cases (3.7%). Fourteen children (17.3%) received chronic anti-epileptic therapy. Interictal EEG abnormalities detected at onset in 20 patients (24.7%) reverted to normal. Transient EEG epileptiform abnormalities were detected in other three cases (3.7%), and a transient photosensitivity in one (1.2%). No recurrence of CwG was observed. Three patients (3.7%) presented with a febrile seizure and two (2.5%) with an unprovoked seizure, but none developed epilepsy. Conclusions: The long-term evaluation of children with CwG confirms the excellent prognosis of this condition, with normal psychomotor development and low risk of relapse and of subsequent epilepsy.File | Dimensione | Formato | |
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