OBJECTIVES: The present pilot study was performed to evaluate the HPA axis and ANS activity by measuring salivary cortisol and α-amylase diurnal trajectory and production, respectively, in mild or moderate-to-severe (MS) OSA-affected, but otherwise healthy, children. Moreover, a correlative analysis was performed between the salivary biomarker concentrations and the PSG variables characterizing the OSA severity. METHODS: We studied 27 consecutive OSA patients (13 mild OSA; 14 MS OSA) and seven healthy children who were enrolled as controls by collecting salivary samples and measuring cortisol and α-amylase levels using enzyme-linked bioassays. RESULTS: Compared with controls, both mild and MS OSA children showed: (1) increased salivary cortisol diurnal production, (2) maintenance of the physiological circadian activity of the HPA axis, and (3) no changes in α-amylase diurnal trajectory and production. In addition, morning salivary cortisol concentrations was negatively associated with the disease severity in the MS OSA group. CONCLUSIONS: OSA is associated with dysregulation of the HPA axis activity in children, the latter potentially underlying some of the adverse consequences of the disease. Pediatr Pulmonol. 2014; 49:1145-1152. © 2014 Wiley Periodicals, Inc
Salivary biomarkers of obstructive sleep apnea syndrome in children / Patacchioli, Francesca Romana; Tabarrini, A; Ghiciuc, Cm; Dima Cozma, Lc; Prete, A; Bianchini, C; Nicoletti, Ferdinando; Gozal, D; Villa, MARIA PIA. - In: PEDIATRIC PULMONOLOGY. - ISSN 8755-6863. - STAMPA. - 49:(2014), pp. 1145-1152. [10.1002/ppul.22972]
Salivary biomarkers of obstructive sleep apnea syndrome in children
PATACCHIOLI, Francesca Romana;NICOLETTI, Ferdinando;VILLA, MARIA PIA
2014
Abstract
OBJECTIVES: The present pilot study was performed to evaluate the HPA axis and ANS activity by measuring salivary cortisol and α-amylase diurnal trajectory and production, respectively, in mild or moderate-to-severe (MS) OSA-affected, but otherwise healthy, children. Moreover, a correlative analysis was performed between the salivary biomarker concentrations and the PSG variables characterizing the OSA severity. METHODS: We studied 27 consecutive OSA patients (13 mild OSA; 14 MS OSA) and seven healthy children who were enrolled as controls by collecting salivary samples and measuring cortisol and α-amylase levels using enzyme-linked bioassays. RESULTS: Compared with controls, both mild and MS OSA children showed: (1) increased salivary cortisol diurnal production, (2) maintenance of the physiological circadian activity of the HPA axis, and (3) no changes in α-amylase diurnal trajectory and production. In addition, morning salivary cortisol concentrations was negatively associated with the disease severity in the MS OSA group. CONCLUSIONS: OSA is associated with dysregulation of the HPA axis activity in children, the latter potentially underlying some of the adverse consequences of the disease. Pediatr Pulmonol. 2014; 49:1145-1152. © 2014 Wiley Periodicals, IncI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.