The invitro antibacterial activities of eight compounds isolated from lichens, collected in several Southern regions of Chile (including Antarctica), were evaluated against methicillin-resistant clinical isolates strains of Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus warneri. The minimum inhibitory concentrations, calculated in microdilution, were ranging from 8 mu gmL(-1) for sphaerophorin to 1024 mu gmL(-1) for fumarprotocetraric acid. These findings suggest, however, that the natural compounds from lichens are good candidates for the individuation of novel templates for the development of new antimicrobial agents or combinations of drugs for chemotherapy.
Antibacterial activity of selected metabolites from Chilean lichen species against methycillin-resistan staphylococci / Giuseppe, Celenza; Bernardetta, Segatore; Domenico, Setacci; Mariagrazia, Perilli; Fabrizia, Brisdelli; Pierangelo, Bellio; Marisa, Piovano; Juan A., Garbarino; Gianfranco, Amicosante; Nicoletti, Marcello. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - 27:17(2013), pp. 1528-1531. [10.1080/14786419.2012.730043]
Antibacterial activity of selected metabolites from Chilean lichen species against methycillin-resistan staphylococci
NICOLETTI, Marcello
2013
Abstract
The invitro antibacterial activities of eight compounds isolated from lichens, collected in several Southern regions of Chile (including Antarctica), were evaluated against methicillin-resistant clinical isolates strains of Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus warneri. The minimum inhibitory concentrations, calculated in microdilution, were ranging from 8 mu gmL(-1) for sphaerophorin to 1024 mu gmL(-1) for fumarprotocetraric acid. These findings suggest, however, that the natural compounds from lichens are good candidates for the individuation of novel templates for the development of new antimicrobial agents or combinations of drugs for chemotherapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
