Galectin-3 has been increasingly recognized as an important modulator of several biological functions, by interacting with several molecules inside and outside the cell, and an emerging player in numerous disease conditions. Galectin-3 exerts various and sometimes contrasting effects according to its location, type of injury, or site of damage. Strong evidence indicates that galectin-3 participates in the pathogenesis of diabetic complications via its receptor function for advanced glycation (AGE) and lipoxidation (ALE) end-products. AGEs/ALEs are produced to an increased extent in target organs of complications, such as kidney and vessels; here, lack of galectin-3 impairs their removal, leading to accelerated damage. In contrast, in the liver, AGE/ALE tissue content and injury are decreased, because lack of galectin-3 results in reduced uptake and tissue accumulation of these by-products. Some of these effects can be explained by changes in the expression of receptor for AGEs (RAGE),

Galectin-3. an emerging all-out player in metabolic disorders and their complications / Pugliese, Giuseppe; Iacobini, Carla; C. M., Pesce; Menini, Stefano. - In: GLYCOBIOLOGY. - ISSN 0959-6658. - 25:2(2015), pp. 136-150. [10.1093/glycob/cwu111]

Galectin-3. an emerging all-out player in metabolic disorders and their complications

PUGLIESE, Giuseppe
Primo
;
IACOBINI, carla
Secondo
;
MENINI, Stefano
Ultimo
2015

Abstract

Galectin-3 has been increasingly recognized as an important modulator of several biological functions, by interacting with several molecules inside and outside the cell, and an emerging player in numerous disease conditions. Galectin-3 exerts various and sometimes contrasting effects according to its location, type of injury, or site of damage. Strong evidence indicates that galectin-3 participates in the pathogenesis of diabetic complications via its receptor function for advanced glycation (AGE) and lipoxidation (ALE) end-products. AGEs/ALEs are produced to an increased extent in target organs of complications, such as kidney and vessels; here, lack of galectin-3 impairs their removal, leading to accelerated damage. In contrast, in the liver, AGE/ALE tissue content and injury are decreased, because lack of galectin-3 results in reduced uptake and tissue accumulation of these by-products. Some of these effects can be explained by changes in the expression of receptor for AGEs (RAGE),
File allegati a questo prodotto
File Dimensione Formato  
Pugliese_Galectin_2014.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 727.18 kB
Formato Adobe PDF
727.18 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pugliese_Galectin-3_2015.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 751 kB
Formato Adobe PDF
751 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/618980
Citazioni
  • ???jsp.display-item.citation.pmc??? 27
  • Scopus 71
  • ???jsp.display-item.citation.isi??? 68
social impact