The extraordinary advancement in developing highly efficient packing materials for liquid chromatography (LC) has only partly touched chiral separations due, in part, to practical problems in synthesis and functionalization of sub-2-μm particles with chiral selectors, and, in part, to the lack of clear understanding of mass-transfer mechanisms in chiral chromatography. However, there is increasing demand for ultrafast chiral separations, mainly from fine chemical and pharmaceutical companies. This review revisits the most important achievements in enantioselective ultra-high-performance LC (eUHPLC) by focusing, in particular, on brush-type chiral stationary phases, as they are the most promising materials for transition from traditional high-performance LC (HPLC) to ultra-high-speed and ultrahigh- pressure regimes. We also attempt to predict possible future trends and solutions that will contribute to making eUHPLC a routine technique in analytical laboratories.

Enantioseparation by Ultra High Performance Liquid Chromatography / A., Cavazzini; N., Marchetti; R., Guzzinati; Pierini, Marco; Ciogli, Alessia; Kotoni, Dorina; D'Acquarica, Ilaria; Villani, Claudio; Gasparrini, Francesco. - In: TRAC. TRENDS IN ANALYTICAL CHEMISTRY. - ISSN 0165-9936. - STAMPA. - 63:(2014), pp. 95-103. [10.1016/j.trac.2014.06.026]

Enantioseparation by Ultra High Performance Liquid Chromatography

PIERINI, MARCO;CIOGLI, Alessia;KOTONI, DORINA;D'ACQUARICA, Ilaria;VILLANI, Claudio;GASPARRINI, Francesco
2014

Abstract

The extraordinary advancement in developing highly efficient packing materials for liquid chromatography (LC) has only partly touched chiral separations due, in part, to practical problems in synthesis and functionalization of sub-2-μm particles with chiral selectors, and, in part, to the lack of clear understanding of mass-transfer mechanisms in chiral chromatography. However, there is increasing demand for ultrafast chiral separations, mainly from fine chemical and pharmaceutical companies. This review revisits the most important achievements in enantioselective ultra-high-performance LC (eUHPLC) by focusing, in particular, on brush-type chiral stationary phases, as they are the most promising materials for transition from traditional high-performance LC (HPLC) to ultra-high-speed and ultrahigh- pressure regimes. We also attempt to predict possible future trends and solutions that will contribute to making eUHPLC a routine technique in analytical laboratories.
2014
Brush-type chiral selector, Chiral stationary phase, Chiral UHPLC, eUHPLC, eUHPSFC, High-throughput chiral analysis, Mass transfer, Stereodynamic, Sub-2-µm particle
01 Pubblicazione su rivista::01a Articolo in rivista
Enantioseparation by Ultra High Performance Liquid Chromatography / A., Cavazzini; N., Marchetti; R., Guzzinati; Pierini, Marco; Ciogli, Alessia; Kotoni, Dorina; D'Acquarica, Ilaria; Villani, Claudio; Gasparrini, Francesco. - In: TRAC. TRENDS IN ANALYTICAL CHEMISTRY. - ISSN 0165-9936. - STAMPA. - 63:(2014), pp. 95-103. [10.1016/j.trac.2014.06.026]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/611987
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 60
  • ???jsp.display-item.citation.isi??? 54
social impact