Background and purpose: Vgf gene expression has been detected in various endocrine and neuronal cells in the gastrointestinal tract. In this study we investigated the pharmacological activity of different VGF-derived peptides. Among these, TLQP-21, corresponding to the 556-576 fragment of the protein was the unique active peptide, and its pharmacological profile was further studied.
In vitro and in vivo pharmacological role of TLQP-21, a VGF-derived peptide, in the regulation of rat motor gastric functions / Petrella, Carla; Agostini, Simona; Improta, Giovanna; Broccardo, Maria; Rinaldi, Am; Levi, A; Possenti, R; Severini, C.. - 157:6(2009), pp. 984-993. (Intervento presentato al convegno 3° riunione scientifica gruppo italiano scienze neuroendocrine tenutosi a Roma; Italy nel 23-24 marzo).
In vitro and in vivo pharmacological role of TLQP-21, a VGF-derived peptide, in the regulation of rat motor gastric functions
PETRELLA, CARLA;AGOSTINI, SIMONA;IMPROTA, Giovanna;BROCCARDO, Maria;
2009
Abstract
Background and purpose: Vgf gene expression has been detected in various endocrine and neuronal cells in the gastrointestinal tract. In this study we investigated the pharmacological activity of different VGF-derived peptides. Among these, TLQP-21, corresponding to the 556-576 fragment of the protein was the unique active peptide, and its pharmacological profile was further studied.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
