We compared the risk factors, the diagnostic tools and the outcome of filamentous fungal infections (FFIs) in hematological patients (HAEs) and non-hematological patients (non-HAEs). Prospective surveillance (2009-2011) of proven and probable FFIs was implemented in 23 Italian hospitals. Out of 232 FFIs, 113 occurred in HAEs and 119 in non-HAEs. The most frequent infection was invasive aspergillosis (76.1 % for HAEs, 56.3 % for non-HAEs), and the localization was principally pulmonary (83.2 % for HAEs, 74.8 % for non-HAEs). Neutropenia was a risk factor for 89.4 % HAEs; the main underlying condition was corticosteroid treatment (52.9 %) for non-HAEs. The distribution of proven and probable FFIs was different in the two groups: proven FFIs occurred more frequently in non-HAEs, whereas probable FFIs were correlated with the HAEs. The sensitivity of the galactomannan assay was higher for HAEs than for non-HAEs (95.3 vs. 48.1 %). The overall mortality rate was 44.2 % among the HAEs and 35.3 % among the non-HAEs. The etiology influenced the patient outcomes: mucormycosis was associated with a high mortality rate (57.1 % for HAEs, 77.8 % for non-HAEs). The epidemiological and clinical data for FFIs were not identical in the HAEs and non-HAEs. The differences should be considered to improve the management of FFIs according to the patients' setting.
SIMIFF study: Italian fungal registry of mold infections in hematological and non-hematological patients / M. T., Montagna; G., Lovero; C., Coretti; D., Martinelli; M., Delia; O., De Giglio; M., Caira; F., Puntillo; D., D'Antonio; Venditti, Mario; V., Sambri; F., Di Bernardo; A., Barbui; G., Lo Cascio; E., Concia; M., Mikulska; C., Viscoli; N., Maximova; A., Candoni; S., Oliveri; G., Lombardi; L., Pitzurra; M., Sanguinetti; R., Masciari; T., Santantonio; S., Andreoni; F., Barchiesi; P., Pecile; C., Farina; P., Viale; G., Specchia; G., Caggiano; L., Pagano. - In: INFECTION. - ISSN 0300-8126. - ELETTRONICO. - 42:1(2014), pp. 141-151. [10.1007/s15010-013-0539-3]
SIMIFF study: Italian fungal registry of mold infections in hematological and non-hematological patients
VENDITTI, Mario;
2014
Abstract
We compared the risk factors, the diagnostic tools and the outcome of filamentous fungal infections (FFIs) in hematological patients (HAEs) and non-hematological patients (non-HAEs). Prospective surveillance (2009-2011) of proven and probable FFIs was implemented in 23 Italian hospitals. Out of 232 FFIs, 113 occurred in HAEs and 119 in non-HAEs. The most frequent infection was invasive aspergillosis (76.1 % for HAEs, 56.3 % for non-HAEs), and the localization was principally pulmonary (83.2 % for HAEs, 74.8 % for non-HAEs). Neutropenia was a risk factor for 89.4 % HAEs; the main underlying condition was corticosteroid treatment (52.9 %) for non-HAEs. The distribution of proven and probable FFIs was different in the two groups: proven FFIs occurred more frequently in non-HAEs, whereas probable FFIs were correlated with the HAEs. The sensitivity of the galactomannan assay was higher for HAEs than for non-HAEs (95.3 vs. 48.1 %). The overall mortality rate was 44.2 % among the HAEs and 35.3 % among the non-HAEs. The etiology influenced the patient outcomes: mucormycosis was associated with a high mortality rate (57.1 % for HAEs, 77.8 % for non-HAEs). The epidemiological and clinical data for FFIs were not identical in the HAEs and non-HAEs. The differences should be considered to improve the management of FFIs according to the patients' setting.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
