Liver disease is associated with qualitative and quanti- tative changes in the intestinal microbiota. In cirrhotic patients the alteration in gut microbiota is characterized by an overgrowth of potentially pathogenic bacteria (i.e. , gram negative species) and a decrease in autoch- thonous familiae. Here we summarize the available literature on the risk of gut dysbiosis in liver cirrhosis and its clinical consequences. We therefore described the features of the complex interaction between gut microbiota and cirrhotic host, the so called “gut-liver axis”, with a particular attention to the acquired risk of bacterial translocation, systemic inflammation and the relationship with systemic infections in the cirrhotic pa- tient. Such knowledge might help to develop novel and innovative strategies for the prevention and therapy of gut dysbiosis and its complication in liver cirrhosis.
Microbiota and the gut-liver axis: bacterial translocation, inflammation and infection in cirrhosis / Giannelli, Valerio; Vincenza Di, Gregorio; Iebba, Valerio; Giusto, Michela; Schippa, Serena; Merli, Manuela; Ulrich, Thalheimer. - In: WORLD JOURNAL OF GASTROENTEROLOGY. - ISSN 1007-9327. - ELETTRONICO. - 20:45(2014), pp. 16795-16810. [10.3748/wjg.v20.i45.16795]
Microbiota and the gut-liver axis: bacterial translocation, inflammation and infection in cirrhosis
GIANNELLI, VALERIO;IEBBA, VALERIO;GIUSTO, MICHELA;SCHIPPA, Serena;MERLI, Manuela;
2014
Abstract
Liver disease is associated with qualitative and quanti- tative changes in the intestinal microbiota. In cirrhotic patients the alteration in gut microbiota is characterized by an overgrowth of potentially pathogenic bacteria (i.e. , gram negative species) and a decrease in autoch- thonous familiae. Here we summarize the available literature on the risk of gut dysbiosis in liver cirrhosis and its clinical consequences. We therefore described the features of the complex interaction between gut microbiota and cirrhotic host, the so called “gut-liver axis”, with a particular attention to the acquired risk of bacterial translocation, systemic inflammation and the relationship with systemic infections in the cirrhotic pa- tient. Such knowledge might help to develop novel and innovative strategies for the prevention and therapy of gut dysbiosis and its complication in liver cirrhosis.File | Dimensione | Formato | |
---|---|---|---|
Giannelli_Microbiota_2014.pdf
accesso aperto
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Creative commons
Dimensione
1.37 MB
Formato
Adobe PDF
|
1.37 MB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.