Hepatitis E virus (HEV) is the most important causative agent of acute hepatitis in developing countries. The disease is usually characterized by a self-limiting, benign course. However, when particular conditions coexist (pregnancy, old age, pre-existing liver disease) it may run an unfavourable course. To date, 4 HEV genotypes have been described. Historically, in the Western world, HEV infection was considered a travel-related disease, however in the last 2 decades a great number of non-travel-related autochthonous cases have been described, more often related to genotype 3 or 4 and in the context of zoonosis. We report the case of an elderly Italian man with an acute fulminant HEV infection genotype 3e that developed in the context of pre-existing liver disease; this is the first case of an unfavourable outcome associated with subgenotype 3e. The potential pathogenicity of this subgenotype together with the influence of host-related risk factors are discussed.
Acute fulminant hepatitis E virus genotype 3e infection: Description of the first case in Europe / Festa, S; Garbuglia, Ar; Baccini, F; Panzuto, F; Capobianchi, Mr; Santino, Iolanda; Purchiaroni, F; Orgera, Gianluigi; DELLE FAVE, Gianfranco; Marignani, M.. - In: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. - ISSN 0036-5548. - STAMPA. - 46:(2014), pp. 727-731. [10.3109/00365548.2014.928417]