After the recent discovery of various mutations of theCALRgene,,10% of adult patients with essential thrombocythemia (ET) orprimary myelofibrosis carry no identified molecular markers.1,2More rarely, ET may occur also in children and adolescents.3Weevaluated, by Sanger sequencing, the mutation status of exon 9 oftheCALRgene in 34 ET patients younger than 20 years of age atdiagnosis (median age, 15 years; range, 1-19 years). The study wasapproved by the Institutional Ethic Committees
CALR mutations in patients with essential thrombocythemia diagnosed in childhood and adolescence / Giona, Fiorina; Teofili, L; Capodimonti, S; Laurino, M; Martini, M; Marzella, D; Palumbo, G; Diverio, D; Foa, Roberto; Larocca, L. M.. - In: BLOOD. - ISSN 0006-4971. - 123:33(2014), pp. 3677-3679. [10.1182/blood-2014-04-572040]
CALR mutations in patients with essential thrombocythemia diagnosed in childhood and adolescence.
GIONA, Fiorina;FOA, Roberto;
2014
Abstract
After the recent discovery of various mutations of theCALRgene,,10% of adult patients with essential thrombocythemia (ET) orprimary myelofibrosis carry no identified molecular markers.1,2More rarely, ET may occur also in children and adolescents.3Weevaluated, by Sanger sequencing, the mutation status of exon 9 oftheCALRgene in 34 ET patients younger than 20 years of age atdiagnosis (median age, 15 years; range, 1-19 years). The study wasapproved by the Institutional Ethic CommitteesFile | Dimensione | Formato | |
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