Background: The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population. Findings. A case-control study, comprising 137 Italian patients with surgically confirmed endometriosis and 120 healthy controls, was carried out. 5-HTT genotypes (LL, SL and SS) were obtained by polymerase chain reaction and gel electrophoresis analysis. We found no overall difference in genotypic and allelic distributions of the 5-HTT gene between cases and controls. Conclusions: Our results suggest that the 5-HTT L/S promoter polymorphism is not associated with susceptibility to endometriosis in the studied Italian patients. © 2014 Megiorni et al.; licensee BioMed Central Ltd.
Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population / Megiorni, Francesca; Resta, Serena; Deliar Yazdanian, Masouleh; Cavaggioni, Gabriele; Claudia, Lia; BENEDETTI PANICI, Pierluigi; Pizzuti, Antonio; Porpora, Maria Grazia. - In: JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE. - ISSN 1477-5751. - STAMPA. - 13:1(2014), p. 12. [10.1186/1477-5751-13-12]
Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population
MEGIORNI, Francesca;RESTA, SERENA;CAVAGGIONI, Gabriele;BENEDETTI PANICI, PIERLUIGI;PIZZUTI, Antonio;PORPORA, Maria Grazia
2014
Abstract
Background: The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population. Findings. A case-control study, comprising 137 Italian patients with surgically confirmed endometriosis and 120 healthy controls, was carried out. 5-HTT genotypes (LL, SL and SS) were obtained by polymerase chain reaction and gel electrophoresis analysis. We found no overall difference in genotypic and allelic distributions of the 5-HTT gene between cases and controls. Conclusions: Our results suggest that the 5-HTT L/S promoter polymorphism is not associated with susceptibility to endometriosis in the studied Italian patients. © 2014 Megiorni et al.; licensee BioMed Central Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
