Snail is the master gene of epithelial–mesenchymal transition (EMT), a program of cell development characterized by loss of cell adhesion, repression of E-cadherin and increased cell mobility. EMT has also been implicated in two of the most important processes responsible for cancer-related mortality: formation of metastasis and acquisition of therapeutic resistance. Recent works have shown that Snail is a necessary factor for the survival of migrating cells and that it plays an important role in therapeutic resistance. The molecular mechanisms that govern the different roles of Snail in tumor progression are poorly understood. Growing evidences indicate that PARP-1 is involved in controlling Snail expression and, taking in consideration Snail cytoprotective role, we assume that PARP-1 contribution to Snail expression modulates the resistance to apoptosis of some types of cancer cells. In this study we investigate whether PARP-1 is involved in the regulation of Snail level upon doxo.
Role of PARP-1 in the regulation of Snail expression in epithelial cancer cells / Mariano, Germano; Zampieri, Michele; Ciccarone, Fabio; Guastafierro, Tiziana; Calabrese, Roberta; Valentini, Elisabetta; Caiafa, Paola; Reale, Anna. - (2013). (Intervento presentato al convegno XXV Convegno “I PROCESSI DI ADP-RIBOSILAZIONE" tenutosi a Pavia nel 31 maggio-1giugno).
Role of PARP-1 in the regulation of Snail expression in epithelial cancer cells
MARIANO, GERMANO;ZAMPIERI, Michele;CICCARONE, FABIO;GUASTAFIERRO, Tiziana;CALABRESE, ROBERTA;VALENTINI, ELISABETTA;CAIAFA, Paola;REALE, Anna
2013
Abstract
Snail is the master gene of epithelial–mesenchymal transition (EMT), a program of cell development characterized by loss of cell adhesion, repression of E-cadherin and increased cell mobility. EMT has also been implicated in two of the most important processes responsible for cancer-related mortality: formation of metastasis and acquisition of therapeutic resistance. Recent works have shown that Snail is a necessary factor for the survival of migrating cells and that it plays an important role in therapeutic resistance. The molecular mechanisms that govern the different roles of Snail in tumor progression are poorly understood. Growing evidences indicate that PARP-1 is involved in controlling Snail expression and, taking in consideration Snail cytoprotective role, we assume that PARP-1 contribution to Snail expression modulates the resistance to apoptosis of some types of cancer cells. In this study we investigate whether PARP-1 is involved in the regulation of Snail level upon doxo.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
